Bisphosphonate Therapy for Osteogenesis Imperfecta
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 18
- 主要终点
- Bone Mineral Density
研究概览
简要总结
The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." We, the researchers at Indiana University School of Medicine, are characterizing the changes effected by oral bisphosphonate therapy and comparing them to a regimen of intravenous bisphosphonate therapy in a group of children with OI and also in children with other disorders that result in low bone mass and fractures.
详细描述
The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." OI is an inherited disorder of collagen synthesis. Collagen is the major structural protein of the matrix of tendons, skin, and bones. Affected persons have low bone mineral density (and experience multiple fractures and progressive bony deformity). In its most severe form, the disorder is lethal in infancy. We plan to characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI.
Additionally, we have begun to treat patients with OI and other conditions of low bone mineralization for age who are not eligible for the standard protocol (too young, history of abdominal pain, etc.) with bisphosphonate. We also plan to screen the parents and siblings of our patients diagnosed with osteogenesis imperfecta, in order to determine if they also have osteoporosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of OI, as defined by genetic analysis revealing a defect of type I collagen, OR by bone mineral density (BMD) <2.5 standard deviations (SD) for age plus two of the following:
- •Family history of OI
- •Frequent fractures
- •Blue sclerae
- •Multiple wormian bones on skull x-ray
- •Hearing disturbance
- •Dentinogenesis imperfecta
- •Age between 3 and 21 years at the start of the study period.
- •Children must be able to swallow whole tablets
- •Parents of children must be able to understand protocol and give informed consent.
排除标准
- •Therapy with bisphosphonates during the past 12 months.
- •Other "non-traditional" therapy for OI in the last 6 months, such as growth hormone or anabolic steroids.
- •Other chronic diseases besides OI that interfere with bone morphology or gastrointestinal absorption
研究组 & 干预措施
Alendronate
1 mg/kg po qd rounded to nearest 10 or 20 mg dose
干预措施: Alendronate (Drug)
Pamidronate
3 mg/kg IV q4 months
干预措施: Pamidronate (Drug)
结局指标
主要结局
Bone Mineral Density
时间窗: 2 years
By Dual-energy x-ray absorptiometry. Results were reported as z-scores as well as as absolute values. The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean with negative numbers indicating values lower than the mean and positive values higher. Higher Z scores indicate a better outcome", or similar, as accurate and appropriate.
次要结局
未报告次要终点
研究者
Linda DiMeglio, MD
MD
Indiana University