IRCT20170122032121N5招募中1 期
: The Safety Evaluation of Ex vivo Activated Haploidentical Natural Killer Cells (NK) in patients with Recurrent Glioblastoma Multiform and resistant/recurrent malignant brain tumor (Clinical Trial Phase I)
Iranian academic center for education culture and research0 个研究点目标入组 5 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 5
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 3 years 至 65 years（—）
- 性别
- All
入选标准
- •Age: 3-65 Year
- •Lansky/Karnofsky performance statue: 7-100%
- •Life span expectation: >6 months
- •Hemoglobin: > 10.0 g/dL
- •AGC > 1,500/mm³
- •Platelet count > 100,000/mm³
- •Serum total bilirubin < 1.5 times upper limit of normal(ULN)
- •ALT and AST < 2.5 times ULN
- •Serum creatinine < 1.5 times
排除标准
- •Patients whose MRI or MRS view of the brain is in favor of radio necrosis
- •Due to emergency conditions, the patient can not tolerate the new treatment
- •Insufficient number of NK cells produced for treatment
- •appearance new neurological ulcers after the first injection (after the wound heals, subsequent injections will be given if the patient is in good condition)
- •diagnosis of any other invasive cancer within the past 5 years.
- •Closing the reservare for the next injection (if this problem is solved, the injections will be done again.
- •concurrent serious medical or psychiatric illness that may interfere with giving informed consent or conducting this study
研究者
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