Nocturnal Blood Pressure in Hypertension, Obstructive Sleep Apnea and Healthy Subjects - Central and Peripheral 24-h Blood Pressure
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- decrease in central systolic blood pressure at night
研究概览
简要总结
A new study have shown that high night time blood pressure (BP) and/or non-dipping (lack of fall in BP during night time) is a strong predictor for the risk of cardiovascular disease and mortality in patients with hypertension. Three factors seem to affect the night time BP: chronic kidney disease, obstructive sleep apnea (OSA) and the way ambulatory blood pressure is monitored.
Hypothesis:
Central 24-h blood pressure monitoring is a better way of monitoring blood pressure than conventional peripheral monitoring.
In hypertension, chronic kidney disease and obstructive sleep apnea (OSA) the night time blood pressure is elevated, and is OSA the elevation is correlated to the severity of OSA.
In OSA the kidneys handling of salt and water is disturbed. In OSA there is disturbances in hormonal balance.
详细描述
75 patients with hypertension and chronic kidney disease (CKD I-II) and 75 healthy subjects is examined with both central and peripheral 24 hours blood pressure monitoring, 1 night home polygraphy to determine whether the subject has obstructive sleep apnea (OSA), and if so the degree (apnea hypopnea index, AHI), blood and urine samples to determine levels of urine aquaporine2 (u-AQP2), urine endothelial sodium channel (u-EnaC), plasma renin concentration (PRC), plasma angiotensin II (p-AngII), plasma aldosterone (p-aldosterone), plasma vasopressin (p-AVP) and plasma endothelin (p-endothelin).
Hypothesis:
Central 24-h BP monitoring provides another measure of daily fluctuations in blood pressure than peripheral 24-h BP monitoring, because this measurement is painless and does not interfere with activities in the daytime or night-time sleep.
In hypertension, chronic kidney disease and OSA the decease in nocturnal BP is lower than i healthy subjects.
In OSA the decrease in the nocturnal BP is inversely correlated with the severity of OSA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 55 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chronic kidney disease (CKD stage I and II), estimated glomerule filtration rate (eGFR) 60-90 ml/min/1.73 m2 or eGFR> 90 ml/min/1.73 m2 and proteinuria or other signs of kidney damage.
- •Hypertension (BP by ambulatory or home blood pressure> 135/85 mmHg, or consultation blood pressure> 140/90 mmHg).
- •Both men and women
- •55-70 years
- •A completed consent form
排除标准
- •Lack of desire to participate
- •In the treatment of OSA
- •Malignant disease
- •Abuse of drugs or alcohol
- •Pregnant and breastfeeding
- •Incompensated heart failure
- •Atrial fibrillation
- •Liver disease (Alanine aminotransferase (ALT)> 200)
- •Severe chronic obstructive pulmonary disease (COPD) (Forced expiratory volume in 1 second <50% predicted)
- •eGFR <60 ml/min/1.73 m2
- •Blood pressure difference between the right and left arm> 10/10 mmHg
- •Group 2 - Healthy subjects
- •Inclusion Criteria:
- •Healthy subjects men and women
- •age 55 - 70 years
- •Body mass index within the normal range, between 18.5 to 25.0 kg/m2
- •Exclusion Criteria:
- •Arterial hypertension, ambulatory blood pressure> 130 mmHg systolic and / or 80 mmHg diastolic.
- •a history or clinical signs of cardial, pulmonary, hepato, renal, endocrine, cerebral or neoplastic disorders
- •Alcohol abuse, ie. > 14 drinks / week for women and> 21/uge for men
- •Substance abuse
- •Medical treatment apart from oral contraceptives
- •Pregnancy or breastfeeding
- •Lack of desire to participate
- •Clinically significant, discrepant results of blood or urine sample at inclusion study (B-hemoglobin and B-White blood cell count, p-sodium, p-potassium, p-creatinine, p-ALT, p-bilirubin , p-Alkaline phosphatase, p-cholesterol, p-albumin or b-glucose and urine for hematuria, albuminuria or glucosuria)
- •Clinically significant variations in the electrocardiogram
- •Blood Donation for the past month preceding the day on the first attempt sequence
- •Blood pressure difference between the right and left arm> 10/10 mmHg.
结局指标
主要结局
decrease in central systolic blood pressure at night
时间窗: < 24 hours
The difference in the decrease in systolic BP at night by peripheral 24-h BP between patients with hypertension and healthy subjects.
次要结局
- decrease in central systolic blood pressure at night(< 24 hours)
- The correlation between the decrease in nighttime BP on one side and severity of OSA and BP in the daytime on the other.(< 24 hours)
- difference i blood pressure levels throughout the day(< 24 hours)
- u-AQP2 and u-ENac(24 hours)
- PRC, p-AngII, p-aldosterone, p-AVP, p-endothelin(< 1 hour)
研究者
Erling Bjerregaard Pedersen
professor
Regional Hospital Holstebro