The αKlotho Protein-mediated NLRP3/Caspase-1/GSDMD Pathway Counteracts Myocardial Stunning: a Novel Mechanism for Exercise to Delay Cardiac Aging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Surface electromyography
研究概览
简要总结
The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(VILPA) within a healthy population.
The main question it aims to answer is:
[1] Does VILPA yield effective outcomes?
Throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. The efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy Adults
- •No exercise habits (more than 3 months)
排除标准
- •Exercising ≥ 3 times per week;
- •the presence of chronic diseases, such as hypertension, hyperglycemic states, etc;
- •have conducted an exercise program in the past three months.
结局指标
主要结局
Surface electromyography
时间窗: 30 minutes
Isometric Strength Test
时间窗: 15 minutes
Isokinetic muscle strength testing with the Isomed 2000
Exercise Flat Test
时间窗: 30 minutes
cardiopulmonary function
次要结局
- Fasting glucose(5 minutes)
- Blood lipid(5 minutes)
研究者
Xiao-dong Zhuang
Clinical Professor
Sun Yat-sen University