NCT02721537已完成不适用
Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes and a Comparison of the Effect of Nicotinamide Riboside Supplementation on Brain NAD+ Levels
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 30
- 试验地点
- 4
- 主要终点
- Change in brain NAD+ levels
研究概览
简要总结
Can nicotinamide riboside (750 mg/day for 12 weeks) affect the levels of NAD+ in the brain as measured by 31P MRS?
详细描述
Healthy collegiate athletes (football, soccer, rugby, hockey, and volleyball) will take Nicotinamide Riboside (NR) or placebo twice daily for 84 days. Pre- and post-intervention evaluations include physical assessment, blood tests for safety and toxicity monitoring, blood tests for biomarkers, neurologic testing, quality of life questionnaires, and the 31P MRI exam.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult current and former (within 2 years) collegiate athletes (football, rugby, soccer, hockey, and volleyball)
- •Body mass index (estimated based on height and weight) from 23 to 37
- •Willing to provide informed consent, ingest test substance, and provide blood specimens
- •Willing to comply with study instructions and maintain current level of physical activity throughout the study
排除标准
- •History of loss of consciousness of more than 5 minutes
- •Contraindications to Magnetic Resonance Imaging (MRI), such as implanted medical devices, metal objects, or pacemakers
- •History of epilepsy
- •History of more than 3 concussions
- •History of headache preceding a concussion
- •History of depression preceding a concussion
- •History of developmental delays or Attention Deficit Hyperactivity Disorder (ADHD)
- •History of post-traumatic seizures
- •History of complex spine and/or skull trauma
结局指标
主要结局
Change in brain NAD+ levels
时间窗: baseline, day 84
As measured by 31P MRI
次要结局
未报告次要终点
研究者
Brent A. Bauer
M.D., Professor of Medicine
Mayo Clinic
研究点 (4)
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