ACTRN12609001007224尚未招募未知
A study of kinins involved in the inflammation and pain associated with osteoarthritis of the knee
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 100 Years（—）
- 性别
- All
入选标准
- •*primary knee osteoarthritis (OA), which has been diagnosed based on clinical and radiographic criteria, according to the American College of Rheumatology(knee pain,either age > 50 or morning stiffness < 30 mins or crepitus, osteophytes)
- •*With radiographic evidence of OA for the studied knee based on retrospective bilateral radiography (within last 12 months): Anterior-posterior view in extension and weight bearing position and sky-line view”; radiographic changes defined by Kellgren-Lawrence score (I to V)
- •*Moderately severe symptoms (> or =40/100 on pain Visual Analogue Scale)
- •*Aged more than 18 years
- •*Able to provide written informed consent
排除标准
- •*Contraindication or unwillingness to undergo an Ultrasound scan
- •*Contraindication or unwillingness to undergo arthrocentesis(including an International normalised ratio greater than 2.0 in subjects on warfarin, or patients on therapeutic dose heparin/ Low Molecular Weight heparin)
- •*Diagnosis of septic arthritis, inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis
- •*With secondary OA, as defined by The Group for the Respect of Ethics and Excellence in Science: septic arthritis, inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis
- •*With injury to the study knee within 6 months of the study start
- •*With a knee joint replacement (partial or total); osteotomy of the studied joint; with arthroscopy of the studied joint made within 1 year of the study start
- •*With an intra articular injection of steroids made within 4 weeks and/or intra articular injection of radionuclide made with 3 months prior to study entry
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