Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome(OSA): EXODYS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- miRNA cointained in exosomes
研究概览
简要总结
Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.
详细描述
The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion.
the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI >15).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult subject
- •Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent
- •Subject with OSA (defined by AHI >15/h)
排除标准
- •cardiac or vascular desease
研究组 & 干预措施
Endothelial dysfunction (DE+)
obsese patient with OSA (AHI>15) and endothelial dysfunction
干预措施: ENDOPAT (Diagnostic Test)
No endothelial dysfunction (DE-)
obsese patient with OSA (AHI>15) and no endothelial dysfunction
干预措施: ENDOPAT (Diagnostic Test)
结局指标
主要结局
miRNA cointained in exosomes
时间窗: immediately after the consultation
compare exosome content between obese-OSA patients with endothelial dysfunction and without
次要结局
未报告次要终点