The Effect of TetraSOD® Supplementation on Blood Oxidative Stress Biomarkers and Endurance Exercise Performance in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Time to exhaustion during a severe-intensity cycle ergometry test continued until exhaustion
研究概览
简要总结
Tetraselmis chuii (TetraSOD) is a marine microalgae that has been reported to improve antioxidant responses in human skeletal muscle cells treated with TetraSOD and to improve recovery from muscle damaging exercise in humans supplemented with TetraSOD. However, the effects of TetraSOD supplementation on endurance performance and physiology is less clear. This study assessed the effect of short-term TetraSOD supplementation on endurance performance and physiology in healthy adults.
详细描述
It is well documented that the production of reactive oxygen species (ROS; unstable molecules that react easily with and damage other molecules in a cell) increases in-line with the intensity and duration of exercise . Although increased ROS production during exercise is initially managed by a variety of 'antioxidants', continued ROS production exceeds the capacity of this antioxidant defense system leading to the development of oxidative stress and impaired exercise performance. Therefore, interventions that can lessen exercise-induced oxidative stress have the potential to improve exercise performance. While dietary supplementation with antioxidant vitamins (e.g. vitamin C and E) has this potential, such interventions do not typically improve exercise performance.
Therefore, further research is required to investigate the potential for novel nutritional supplements to lessen exercise-induced oxidative stress and to improve exercise performance.
Tetraselmis chuii (TetraSOD) is a natural marine microalgae product. Recent preliminary evidence suggests that treating human skeletal muscle cells with TetraSOD can increase the production of antioxidant enzymes to limit oxidative stress development. In addition, TetraSOD supplementation has been reported to improve recovery from muscle damaging exercise. However, the effects of TetraSOD supplementation on endurance performance and physiology is less clear.
The purpose of this study was to assess the effect of short-term TetraSOD supplementation on endurance performance and physiology in healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Funder
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male (as determined by the Health Screening Questionnaire)
- •Adult (aged ≥18 and ≤40 years old)
- •Recreationally-active (≥2 and ≤4 exercise sessions per week) and a V̇O2max of ≥ 35 mL/kg/min and ≤ 65 mL/kg/min as determined from the preliminary exercise test
- •No known history of gastric, digestive, cardiovascular, renal disease or any other orthopaedic diseases related to motor organs
- •Non-smoker
- •Healthy body mass index (BMI; ≥18.5 and ≤24.9 kg/m2)
- •Not using any dietary supplements, including antioxidant and nitrate-rich supplements, currently or in the past one month
- •Not a heavy drinker (≤ 14 units of alcohol) on most weeks
- •Not using medication that may affect study measures
- •Not participating in other studies currently or in the past two months prior to the consenting session (visit 1) or having an intention to participate in other studies over the period of this study
排除标准
- •Aged <18 and >40 years old
- •Sedentary or highly trained with a respective V̇O2max of < 35 mL/kg/min and > 65 mL/kg/min as determined from the preliminary exercise test
- •History of gastric, digestive, cardiovascular, renal disease or any other orthopaedic diseases related to motor organs
- •Unhealthy body mass index (BMI;<18.5 and >24.9 kg/m2)
- •Using any dietary supplements, including antioxidant and nitrate-rich supplements, currently or in the past one month
- •Heavy drinker (> 14 units of alcohol) on most weeks
- •Using medication that may affect study measures
- •Participating in other studies currently or in the past two months prior to the consenting session (visit 1) or having an intention to participate in other studies over the period of this study
研究组 & 干预措施
Placebo-Pre
No supplementation prior to undergoing the placebo supplement
干预措施: Placebo-Pre (Other)
Placebo-post
Placebo supplementation
干预措施: Placebo-Post (Dietary Supplement)
Tetraselmis chuii-Pre
No supplementation prior to undergoing the Tetraselmis chuii supplement
干预措施: Tetraselmis chuii-Pre (Other)
Tetraselmis chuii-Post
Tetraselmis chuii supplementation
干预措施: Tetraselmis chuii-Post (Dietary Supplement)
结局指标
主要结局
Time to exhaustion during a severe-intensity cycle ergometry test continued until exhaustion
时间窗: One assessment prior to and 14 days following the placebo supplementation, and one assessment prior to and 14 days following Tetraselmis chuii supplementation
Time to exhaustion during severe-intensity cycle ergometry measured in seconds
End-exercise pulmonary oxygen uptake during a severe-intensity cycle ergometry test continued until exhaustion measured using an online gas analyser
时间窗: One assessment prior to and 14 days following the placebo supplementation, and one assessment prior to and 14 days following Tetraselmis chuii supplementation
Pulmonary oxygen uptake at the end of a severe-intensity cycling bout completed until exhaustion to provide an estimate of VO2max measured in L/min using a breath-by-breath gas exchange analyzer and taken as the mean over the final 30 s of the test.
次要结局
- End-exercise blood lactate concentration during a severe-intensity cycle ergometry test continued until exhaustion(One assessment prior to and 14 days following the placebo supplementation, and one assessment prior to and 14 days following Tetraselmis chuii supplementation)
- End-exercise rating of perceived exertion using the Borg 6-20 scale during a severe-intensity cycle ergometry test continued until exhaustion(One assessment prior to and 14 days following the placebo supplementation, and one assessment prior to and 14 days following Tetraselmis chuii supplementation)
研究者
Stephen Bailey
Reader in Human and Exercise Physiology
Loughborough University