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临床试验/NCT03904810
NCT03904810已完成不适用

The Effectiveness of Low-frequency High-Intensity Interval Training (HIIT) in Overweight or Obese Young Adults

The University of Hong Kong1 个研究点 分布在 1 个国家目标入组 103 人开始时间: 2016年10月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
103
试验地点
1
主要终点
Body weight

研究概览

简要总结

Background: The relationship between the frequency of high-intensity interval training (HIIT) and the resultant adaptations is largely unclear. Purpose: This study examined the effects of different frequencies of HIIT compared to moderate-intensity continuous training (MICT) on body composition and cardiovascular biomarkers in overweight or obese adults. Methods: This study was a randomized, controlled, single-blinded trial. Fifty-six overweight or obese men aged between 18 and 30 years were randomly assigned to no-intervention control (CON; n=14), MICT performed thrice weekly (MICT×3/wk; n=9), HIIT performed thrice weekly (HIIT×3/wk; n=14), HIIT performed twice weekly (HIIT×2/wk; n=10), and HIIT performed once weekly (HIIT×1/wk; n=9). Each HIIT session consisted of 12 × 1-min bouts at 90% heart rate reserve (HRR), interspersed with 11 × 1-min bouts at 70% HRR (HIIT×3/wk: 69 min/wk; HIIT×2/wk: 46 min/wk; HIIT×1/wk: 23 min/wk). Aerobic capacity, resting heart rate, body composition, waist circumference, blood pressure, endothelial function, fasting blood glucose and lipids, circulatory adipokines and inflammatory biomarkers were examined at baseline, after 4 weeks and 8 weeks of intervention.

详细描述

Individuals who fulfilled the following inclusion criteria were invited to participate in the present study: 1) Chinese male; 2) aged 18-30 years; and 3) overweight or obesity, defined as BMI ≥23 kg/m2 (classification of overweight for Hong Kong adults according to Department of Health, Hong Kong SAR Government) (13). Subjects were excluded if they had: 1) chronic medical and health condition such as cardiovascular diseases, diabetes, neurological disease, musculoskeletal disorder, cancers, and autoimmune diseases; 2) hypertension (blood pressure >140/90 mmHg); 3) contraindications to participating in physical exercise; 4) any pre-existing medical or physical issues that affected the experimental test; 5) physically active (i.e., >3 hours of moderate-intensity exercise weekly) or 6) lean overweight population (BMI ≥23 kg/m2, but percent body fat ≤20%) according to the BMI data corresponding to bioelectrical impedance estimated percent body fat cut-off value among Hong Kong Chinese adults.

Of those who were screened, 103 Chinese young adults were eligible to participate in this study. They were provided with written and verbal information on the study protocol and the possible associated discomforts and risks followed by obtaining their written informed consent to participate in this study. The study protocol and consent form were approved by the Human Subjects Ethics Sub-Committee of The Hong Kong Polytechnic University (ethics approval reference number: HSEARS20160927005-01).

This study was a single-blind, randomized, controlled trial. Subjects were randomly assigned to 1) no-intervention control (CON), 2) MICT performed thrice weekly (MICTx3/wk), 3) HIIT performed thrice weekly (HIITx3/wk), 4) twice weekly (HIITx2/wk), and 5) once weekly (HIITx1/wk). All subjects were instructed to maintain their usual daily activities. Outcome measures including aerobic capacity, body composition, blood pressure, resting heart rate, endothelial function, arterial stiffness, fasting glucose, lipids markers, adipokine marker, and inflammatory marker were assessed at baseline, 4 weeks and 8 weeks after the intervention.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Chinese male
  • Aged 18-30 years
  • Overweight or obesity, defined as BMI ≥23 kg/m2 (classification of overweight for Hong Kong adults according to Department of Health, Hong Kong SAR Government)

排除标准

  • Chronic medical and health condition such as cardiovascular diseases, diabetes, neurological disease, musculoskeletal disorder, cancers, and autoimmune diseases
  • Hypertension (blood pressure >140/90 mmHg)
  • Contraindications to participating in physical exercise
  • Any pre-existing medical or physical issues that affected the experimental test
  • Physically active (i.e., >3 hours of moderate-intensity exercise weekly)
  • Lean overweight population (BMI ≥23 kg/m2, but percent body fat ≤20%) according to the BMI data corresponding to bioelectrical impedance estimated percent body fat cut-off value among Hong Kong Chinese adults.

研究组 & 干预措施

Control

No Intervention

Subjects in this group do not received any intervention

Moderate Intensity Continuous Training ×3/wk

Active Comparator

Subjects in this group will receive three sessions of Moderate-Intensity Continuous Training per week throughout the 8 weeks experimental period

干预措施: Exercise intervention (Behavioral)

High Intensity Interval Training×3/wk

Active Comparator

Subjects in this group will receive three sessions of High-Intensity Interval Training per week throughout the 8 weeks experimental period

干预措施: Exercise intervention (Behavioral)

High Intensity Interval Training×2/wk

Active Comparator

Subjects in this group will receive two session of High-Intensity Interval Training per week throughout the 8 weeks experimental period

干预措施: Exercise intervention (Behavioral)

High Intensity Interval Training×1/wk

Active Comparator

Subjects in this group will receive one session of High-Intensity Interval Training per week throughout the 8 weeks experimental period

干预措施: Exercise intervention (Behavioral)

结局指标

主要结局

Body weight

时间窗: 8 weeks

Body weight in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

Total running distance

时间窗: 8 weeks

Total running distance in meters achieved during the 20-meter shuttle multistage run test were used for the assessment of aerobic fitness

Total fat-free mass

时间窗: 8 weeks

Total body fat-free mass were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

Total body fat mass

时间窗: 8 weeks

Total body fat mass in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

Total body fat-free mass percentage

时间窗: 8 weeks

Total body fat-free mass percentage were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

Total body fat percentage

时间窗: 8 weeks

Total body fat percentage were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

Body height

时间窗: 8 weeks

Body height in meter were assessed.

Estimated maximal oxygen consumption

时间窗: 8 weeks

Estimated maximal oxygen consumption achieved during the 20-meter shuttle multistage run test were used for the assessment of aerobic fitness Unit: body weight, estimated oxygen consumption and minute will be combined to report the estimated VO2max in ml/kg/min.

Trunk fat mass

时间窗: 8 weeks

Trunk fat mass in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).

Body mass index (BMI)

时间窗: 8 weeks

Weight and height will be combined to report BMI in kg/m\^2

Waist circumference

时间窗: 8 weeks

Waist circumference was determined to the nearest 0.1 cm of a contact tension tape. The tape was applied directly to the skin at the mid-point between the lower margin of the last palpable rib and the top of the iliac crest.

次要结局

  • Diastolic blood pressure(8 weeks)
  • Mean arterial pressure(8 weeks)
  • Resting heart rate(8 weeks)
  • Interleukin 6(8 weeks)
  • Tumor necrosis factor alpha(8 weeks)
  • Endothelial function(8 weeks)
  • Systolic blood pressure(8 weeks)
  • Arterial stiffness(8 weeks)
  • Serum fasting glucose(8 weeks)
  • Triglycerides(8 weeks)
  • High-density lipoproteins (HDL) cholesterol(8 weeks)
  • Low-density lipoprotein (LDL) cholesterol(8 weeks)
  • C-reactive protein(8 weeks)
  • Adiponectin(8 weeks)
  • Intercellular adhesion molecule-1(8 weeks)
  • Vascular cell adhesion molecule-1(8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Parco M. Siu, PhD

Associate professor

The University of Hong Kong

研究点 (1)

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