NL-OMON26278尚未招募不适用
Effect of oral Curcumin on Gut Microbiota Composition in patients with Diabetes Type II, Ulcerative Colitis, Crohn's disease and healthy subjects
none0 个研究点目标入组 40 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Aged 18-65 years
- •- Stable therapy (i.e. no major dosage changes in the last three months)
- •- Able to give written informed consent
排除标准
- •- Tobacco use (as there are indications this influences the gut microbiota, Huang et al. 2019)
- •- Alcohol use > 1 units/day,
- •- Excessive weight loss of >10% in the last 3 months,
- •- Levels of plasma aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) 2.5 times or more the upper limit of the normal range,
- •- Other liver abnormalities,
- •- Known intolerance to curcumin or curcumin-derivatives,
- •- Use of food supplements containing curcumin or/and black pepper for at least 3 days prior to each study day and two weeks prior to the study,
- •- Daily use of non-steroidal anti-inflammatory drugs (NSAIDS),
- •- Use of proton pump inhibitors (as this influences intestinal microbiota composition)
- •- Eating/drinking of grapefruit and grapefruit-containing products or star fruit during the course of the study,
- •- Incomplete information or unwillingness to comply with the intervention,
- •- Participation in other intervention studies 3 months before or after the duration of this study.
研究者
相似试验
尚未招募
Unknown
Exploratory study of the effect on gut microbiota by ingestion of oligosaccharide.Healthy adultJPRN-UMIN000052735Meiji Co., Ltd.49
进行中（未招募）
不适用
How do polyphenols, carotenoids and glucosinolates in our diets affect the diversity of our gut microbiome?utrition effects on gut microbiomeNutritional, Metabolic, EndocrineISRCTN14510401Quadram Institute27
已完成
1 期
Assessment of the influence of the gut microbiome on tacrolimus pharmacokinetics in healthy volunteersPharmacokinetic trial in healthy volunteersDRKS00032072niversitätsklinikum Heidelberg, Im Wege der Auftragsverwaltung für die Universität Heidelberg, Medizinische Fakultät Heidelberg20
已完成
不适用
The effect of modulating gut microflora on clinical outcome in elective surgical patients.SepsisISRCTN15806146Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)80
招募中
不适用
Evaluation of the use of Probiotics in the intestinal flora, nutritional status and immune system of patients who underwent Surgery to Remove the Stomach for Gastric CancerGastric NeoplasmsGastrectomyG06.591.375RBR-5vyr8bpFAM- Universidade Federal do Amazonas