The Role of Optic Nerve Sheath Fenestration in Leukemic Patients Having Increased Intracranial Pressure
试验速览
- 阶段
- 2 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Visual acuity using LOGMAR
研究概览
简要总结
Optic nerve sheath fenestration (ONSF) first described by De Wecker in 1872 for the treatment of neuroretinitis. Since then, optic nerve sheath fenestration has become well established procedure for treatment of papilledema in medically uncontrolled patients of idiopathic intracranial hypertension.
详细描述
Optic nerve sheath fenestration (ONSF) first described by De Wecker in 1872 for the treatment of neuroretinitis. Since then optic nerve sheath fenestration has become well established procedure for treatment of papilledema in medically uncontrolled patients of idiopathic intracranial hypertension. Indications for ONSF in cancer patients are not well established, but a few case reports have shown success of ONSF in patients with perineural metastasis of breast cancer, increased intracranial pressure with papilledema due to a brain tumor, leukemia and optic nerve sheath meningioma. This study is conducted to establish the role of optic nerve sheath Fenestration in leukemic patients mainly those suffering from acute lymphoblastic leukemia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Evidence of progressive visual loss and papilledema did not improve despite the maximal medical therapy prescribed.
- •Informed written consent was obtained from the parents/care providers of the study participants.
排除标准
- •Can not get the informed consent
结局指标
主要结局
Visual acuity using LOGMAR
时间窗: Three months
Visual acuity using LOGMAR
Papilledema grading using frisén scale
时间窗: Three months
Papilledema grading using frisén scale
次要结局
- Visual acuity using LOGMAR(2 weeks)
- Papilledema grading using frisén scale(2 weeks)
研究者
Mohamed Fahmy Doheim
Dr.
Alexandria University