Cluster Headache (CH), Addictions and Vascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Severity of attacks
研究概览
简要总结
Cluster headache (CH) is one of the most painful primitive headaches. Developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions. CH has strong links to the vascular system but there is no study measuring endothelial function in CH sufferers.
详细描述
Several studies have shown an association between Cluster headache (CH) and smoking. However, no data exists on the link between CH and other addictions, and impact of these addictions on clinical characteristics of the disease. In addition, despite the strong biological link between CH and the vascular system, systematic investigations about vascular functions in CH patients are lacking.
This will be a prospective cohort study of 150 patients with CH, conducted in the Headache Center in Bordeaux, France.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presenting a chronic or episodic cluster headache diagnosed according to the International Classification of Headache Disorders (ICH-D III) criteria, in active or inactive phase.
排除标准
- •Other primary headaches
- •Subjects without social insurance
结局指标
主要结局
Severity of attacks
时间窗: one year after inclusion
Duration of cluster headache
时间窗: one year after inclusion
Duration of active periods of cluster headache
时间窗: one year after inclusion
Number of active periods
时间窗: one year after inclusion
次要结局
- Existence of an addiction(One year after inclusion)
- Severity of Addiction(One year after inclusion)
- Reactive Hyperemic Index (RHI)(Day 0 (Inclusion visit))