Neural Mechanisms of Social Feedback Evaluation in Schizotypy: An EEG Study of Oscillatory and Event-Related Potentials
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Frontal Midline Theta Power (4-7 Hz)
研究概览
简要总结
This study will examine how young adults with different levels of schizotypal traits process social acceptance and rejection. Participants between 18 and 35 years old will complete a single laboratory session that includes questionnaires and electroencephalography (EEG), a noninvasive method that measures electrical brain activity through sensors placed on the scalp. During EEG recording, participants will complete a computer-based Social Judgment Paradigm (SJP) in which they form expectations about whether another person will like or dislike them and then receive experimentally controlled acceptance or rejection feedback. The study will examine how brain responses differ when social feedback is expected versus unexpected and whether these responses vary with schizotypal traits. The goal is to better understand the brain mechanisms involved in evaluating social feedback. This study does not provide treatment and does not test a drug or medical device.
详细描述
Schizotypal traits occur along a continuum in the general population and are associated with differences in social functioning and social information processing. This study will investigate neural responses to social feedback in young adults across the schizotypy spectrum using electroencephalography (EEG).
Participants between 18 and 35 years old will complete a single experimental session. During EEG recording, they will perform a Social Judgment Paradigm (SJP) in which they first form an expectation about whether another person will respond positively or negatively toward them and subsequently receive acceptance or rejection feedback. This produces four within-participant feedback conditions: expected acceptance, expected rejection, unexpected acceptance, and unexpected rejection.
The study will examine brain activity associated with evaluating social feedback, including frontal-midline (FM) theta activity and event-related potentials (ERPs). The primary analyses will test whether neural responses to acceptance and rejection, particularly when feedback violates expectations, vary as a function of continuous schizotypal traits. Participants will also complete self-report measures assessing schizotypal traits, social functioning, and related psychological characteristics.
The study is designed to clarify neural mechanisms involved in social feedback evaluation and to determine how individual differences in schizotypal traits are associated with these processes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 18-35 years.
- •Able to provide informed consent.
- •Able to complete an EEG recording session.
排除标准
- •Younger than 18 years or older than 35 years.
- •Unable to provide informed consent.
- •Unable to complete the EEG recording session.
- •No additional exclusion criteria are applied.
研究组 & 干预措施
Social Judgment Paradigm
Participants complete a single-session Social Judgment Paradigm during EEG recording. All participants experience four within-subject experimental conditions defined by feedback expectancy (expected versus unexpected) and feedback valence (acceptance versus rejection): expected acceptance, expected rejection, unexpected acceptance, and unexpected rejection. The order of feedback trials is randomized within the task.
干预措施: Social Judgment Paradigm (Behavioral)
结局指标
主要结局
Frontal Midline Theta Power (4-7 Hz)
时间窗: Day 1
Mean frontal-midline theta-band power (4-7 Hz) derived from EEG data time-locked to feedback onset during the Social Judgment Paradigm, quantified during the prespecified 200-600 ms post-feedback window at frontocentral electrodes. Theta power will be measured directly across the four feedback conditions defined by expectancy (expected/unexpected) and feedback valence (acceptance/rejection).
Feedback-Related Negativity (FRN) Amplitude
时间窗: Day 1
Mean event-related potential (ERP) amplitude within the 250-350 ms time window following feedback onset during the Social Judgment Paradigm, quantified at frontocentral electrodes. FRN amplitude will be measured directly across the four feedback conditions defined by expectancy and feedback valence.
Late Positive Potential (LPP) Amplitude
时间窗: Day 1
Mean event-related potential (ERP) amplitude within the 350-600 ms time window following feedback onset during the Social Judgment Paradigm, quantified at midline electrodes. LPP amplitude will be measured directly across the four feedback conditions defined by expectancy and feedback valence.
次要结局
- Behavioral Expectancy Responses(Day 1)
- Schizotypal Personality Questionnaire (SPQ) Total Score(Day 1)
- Multidimensional Schizotypy Scale (MSS) Scores(Day 1)
- Brief Fear of Negative Evaluation Scale-Revised (BFNES-R) Total Score(Day 1)
- Perceived Stress Reactivity Scale (PSRS) Total Score(Day 1)
- Social Functioning Questionnaire (SFQ) Total Score(Day 1)