Motor Recovery of Stroke Patients Based on Electroencephalogram-functional Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- Fugl-Meyer scores (T1)
研究概览
简要总结
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
详细描述
A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age above 18 and below 75 years
- •Motor impairment in National Institutes of Health Stroke Scale
- •7-14 days since stroke attack
- •First-ever ischemic stroke
排除标准
- •Motor impairment induced by non-stroke aetiology
- •Claustrophobia; recognition disorder
- •History of other severe central nervous system diseases
- •Any signs unfit for MRI/EEG scan
结局指标
主要结局
Fugl-Meyer scores (T1)
时间窗: 6 weeks since stroke
a scale widely used to evaluate one's motor impairment
Fugl-Meyer scores (T0)
时间窗: 7-14 days since stroke
a scale widely used to evaluate one's motor impairment
Fugl-Meyer scores (T2)
时间窗: 12 weeks since stroke
a scale widely used to evaluate one's motor impairment
Fugl-Meyer scores (T3)
时间窗: 72 weeks since stroke
a scale widely used to evaluate one's motor impairment
次要结局
- Neuroimage features based on EEG-fMRI (T3)(72 weeks since stroke)
- Neuroimage features based on EEG-fMRI (T0)(7-14 days since stroke)
- Neuroimage features based on EEG-fMRI (T1)(6 weeks since stroke)
- Neuroimage features based on EEG-fMRI (T2)(12 weeks since stroke)
研究者
Wentao Zeng
PhD candidate
Health Science Center of Xi'an Jiaotong University