The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,083
- 试验地点
- 1
- 主要终点
- Epicardial Fat Tissue
研究概览
简要总结
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients.
详细描述
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue, which is composed of adipose tissue deposited between the myocardium and the visceral layer of the pericardium. It is closely adjacent to the coronary arteries and myocardium. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients. This study intends to observe the relationship between epicardial fat thickness and left and right functions in patients with HFpEF, and evaluate whether epicardial fat thickness can be used as an indicator of left and right dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult aged >=18years old;
- •Diagnosed with HFpEF.
- •Diagnostic criteria including:
- •left ventricular ejection fraction ≥50%；
- •with the symptoms and/or signs of heart failure；
- •BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
- •at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
排除标准
- •LVEF less than 45% at any time;
- •Severe liver failure;
- •Primary pulmonary hypertension;
- •Age <18 years old.
结局指标
主要结局
Epicardial Fat Tissue
时间窗: On admission
Epicardial Fat Tissue by cardiac color Doppler ultrasound
Cardiac Function
时间窗: On admission
Left ventricular diastolic function and right ventricular systolic function by cardiac color Doppler ultrasound
Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death
时间窗: From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years
Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death
次要结局
- Worsening HF Event(From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years)
- CV Death(From date of discharge until the date of death, whichever came first, assessed up to 10 years)
- All-cause Death(From date of discharge until the date of death, whichever came first, assessed up to 10 years)
研究者
Dongying Zhang
Dongying Zhang
Chongqing Medical University