Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- inflammatory proteins in erythema migrans patients
研究概览
简要总结
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis and to define new immune modulators that could serve as biomarkers of disease activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •erythema migrans in patients > 18 years
排除标准
- •pregnancy or immunocompromising conditions
- •taking antibiotic with antiborrelial activity within 10 days
研究组 & 干预措施
erythema migrans patients treated with doxycycline
adult patients with erythema migrans will be treated with oral doxycycline
干预措施: Doxycycline 7 days (Drug)
erythema migrans patients treated with doxycycline
adult patients with erythema migrans will be treated with oral doxycycline
干预措施: Doxycycline 14 days (Drug)
结局指标
主要结局
inflammatory proteins in erythema migrans patients
时间窗: up to 12 months follow-up
The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses in serum and if available, skin, of patients during active infection and after treatment.
次要结局
- gene polymorphisms in erythema migrans patients(at enrollment)
研究者
Daša Stupica
Principal Investigator
University Medical Centre Ljubljana