Effects of Vitamin D Supplementation on Biochemical Responses and Aerobic Capacity After Strenuous Endurance Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Concentration of CD4+
研究概览
简要总结
The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).
详细描述
All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
A double-blind, matched-pair study design
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The volunteers included have conditions as stated below :
- •no history of cardiovascular, liver, kidney and diabetes disease
- •no acute sport injury
- •male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min
- •did not participated in any clinical trials or research in the last 3 months before our experiment
- •no supplements were taken during the experimental period
- •were requested to maintain their regular daily life style and avoid alcohol intake
排除标准
- •The volunteers were excluded if they have the situation stated below:
- •history of cardiovascular, liver, kidney and diabetes disease
- •acute sport injury
- •their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/min
- •participated in any clinical trials or experimental research in the last 3 months before our experiment
- •taking supplement during the experimental period
- •did not maintain their regular eating habit or drink alcohol
研究组 & 干预措施
Placebo group
干预措施: Medium-chain triglycerides (Dietary Supplement)
Vitamin D group
干预措施: Vitamin D (Dietary Supplement)
结局指标
主要结局
Concentration of CD4+
时间窗: 24-hour after exercise
Concentration of Neutrophil
时间窗: 24-hour after exercise
Concentration ofNeutrophil
时间窗: immediately after exercise
Concentration of eosinophil
时间窗: 24-hour after exercise
Concentration of basophil
时间窗: 24-hour after exercise
Concentration of monocyte
时间窗: 24-hour after exercise
Concentration of lymphocyte
时间窗: 24-hour after exercise
Concentration of CD8+
时间窗: 24-hour after exercise
Concentration of CD19+
时间窗: 24-hour after exercise
Concentration of CD56+
时间窗: 24-hour after exercise
Concentration of IgA
时间窗: 24-hour after exercise
Concentration of Cathelicidin
时间窗: 24-hour after exercise
Concentration of TNF-α
时间窗: 24-hour after exercise
Concentration of IL-1β
时间窗: 24-hour after exercise
Concentration of IFN-γ
时间窗: 24-hour after exercise
Concentration of IL-2
时间窗: 24-hour after exercise
Concentration of IL-4
时间窗: 24-hour after exercise
Concentration of IL-8
时间窗: 24-hour after exercise
Concentration of IL-10
时间窗: 24-hour after exercise
Concentration of TBARS
时间窗: 24-hour after exercise
Concentration of PC
时间窗: 24-hour after exercise
Concentration of SOD
时间窗: 24-hour after exercise
Concentration of catalase
时间窗: 24-hour after exercise
Concentration of GPx
时间窗: 24-hour after exercise
Concentration of CK
时间窗: 24-hour after exercise
Concentration of LDH
时间窗: 24-hour after exercise
Concentration of IL-6
时间窗: 24-hour after exercise
Concentration of CRP
时间窗: 24-hour after exercise
Concentration of basophil
时间窗: 8-hour after exercise
Concentration of monocyte
时间窗: immediately after exercise
Concentration of monocyte
时间窗: 2-hour after exercise
Concentration of monocyte
时间窗: 4-hour after exercise
Concentration of monocyte
时间窗: 8-hour after exercise
Concentration of lymphocyte
时间窗: before exercise
Concentration of lymphocyte
时间窗: immediately after exercise
Concentration of lymphocyte
时间窗: 2-hour after exercise
Concentration of lymphocyte
时间窗: 4-hour after exercise
Concentration of lymphocyte
时间窗: 8-hour after exercise
Concentration of CD4+
时间窗: before exercise
Concentration of eosinophil
时间窗: 8-hour after exercise
Concentration of basophil
时间窗: before exercise
Concentration of basophil
时间窗: immediately after exercise
Concentration of basophil
时间窗: 2-hour after exercise
Concentration of basophil
时间窗: 4-hour after exercise
Concentration of CD4+
时间窗: immediately after exercise
Concentration of CD4+
时间窗: 2-hour after exercise
Concentration of CD4+
时间窗: 4-hour after exercise
Concentration of Neutrophil
时间窗: before exercise
Concentration of Neutrophil
时间窗: 2-hour after exercise
Concentration of Neutrophil
时间窗: 4-hour after exercise
Concentration of Neutrophil
时间窗: 8-hour after exercise
Concentration of eosinophil
时间窗: before exercise
Concentration of CD4+
时间窗: 8-hour after exercise
Concentration of CD8+
时间窗: before exercise
Concentration of CD8+
时间窗: immediately after exercise
Concentration of CD8+
时间窗: 2-hour after exercise
Concentration of CD8+
时间窗: 4-hour after exercise
Concentration of CD8+
时间窗: 8-hour after exercise
Concentration of CD19+
时间窗: before exercise
Concentration of CD19+
时间窗: immediately after exercise
Concentration of CD19+
时间窗: 2-hour after exercise
Concentration of CD19+
时间窗: 4-hour after exercise
Concentration of CD19+
时间窗: 8-hour after exercise
Concentration of CD56+
时间窗: immediately after exercise
Concentration of CD56+
时间窗: 2-hour after exercise
Concentration of CD56+
时间窗: 4-hour after exercise
Concentration of CD56+
时间窗: 8-hour after exercise
Concentration of IgA
时间窗: before exercise
Concentration of IgA
时间窗: immediately after exercise
Concentration of IgA
时间窗: 2-hour after exercise
Concentration of IgA
时间窗: 4-hour after exercise
Concentration of IgA
时间窗: 8-hour after exercise
Concentration of Cathelicidin
时间窗: before exercise
Concentration of Cathelicidin
时间窗: immediately after exercise
Concentration of Cathelicidin
时间窗: 2-hour after exercise
Concentration of Cathelicidin
时间窗: 4-hour after exercise
Concentration of Cathelicidin
时间窗: 8-hour after exercise
Concentration of TNF-α
时间窗: before exercise
Concentration of TNF-α
时间窗: immediately after exercise
Concentration of TNF-α
时间窗: 2-hour after exercise
Concentration of TNF-α
时间窗: 4-hour after exercise
Concentration of TNF-α
时间窗: 8-hour after exercise
Concentration of IL-1β
时间窗: before exercise
Concentration of IL-1β
时间窗: immediately after exercise
Concentration of IL-1β
时间窗: 2-hour after exercise
Concentration of IL-1β
时间窗: 4-hour after exercise
Concentration of IL-1β
时间窗: 8-hour after exercise
Concentration of IFN-γ
时间窗: immediately after exercise
Concentration of IFN-γ
时间窗: 2-hour after exercise
Concentration of IFN-γ
时间窗: 4-hour after exercise
Concentration of IFN-γ
时间窗: 8-hour after exercise
Concentration of IL-2
时间窗: before exercise
Concentration of IL-2
时间窗: immediately after exercise
Concentration of IL-2
时间窗: 2-hour after exercise
Concentration of IL-2
时间窗: 4-hour after exercise
Concentration of IL-2
时间窗: 8-hour after exercise
Concentration of IL-4
时间窗: before exercise
Concentration of IL-4
时间窗: immediately after exercise
Concentration of IL-4
时间窗: 2-hour after exercise
Concentration of IL-4
时间窗: 4-hour after exercise
Concentration of IL-4
时间窗: 8-hour after exercise
Concentration of IL-8
时间窗: before exercise
Concentration of IL-8
时间窗: immediately after exercise
Concentration of IL-8
时间窗: 2-hour after exercise
Concentration of IL-8
时间窗: 4-hour after exercise
Concentration of IL-8
时间窗: 8-hour after exercise
Concentration of IL-10
时间窗: before exercise
Concentration of IL-10
时间窗: immediately after exercise
Concentration of IL-10
时间窗: 2-hour after exercise
Concentration of IL-10
时间窗: 4-hour after exercise
Concentration of IL-10
时间窗: 8-hour after exercise
Concentration of TBARS
时间窗: immediately after exercise
Concentration of TBARS
时间窗: 2-hour after exercise
Concentration of TBARS
时间窗: 4-hour after exercise
Concentration of TBARS
时间窗: 8-hour after exercise
Concentration of monocyte
时间窗: before exercise
Concentration of CD56+
时间窗: before exercise
Concentration of PC
时间窗: before exercise
Concentration of PC
时间窗: immediately after exercise
Concentration of PC
时间窗: 2-hour after exercise
Concentration of PC
时间窗: 4-hour after exercise
Concentration of SOD
时间窗: immediately after exercise
Concentration of SOD
时间窗: 2-hour after exercise
Concentration of SOD
时间窗: 4-hour after exercise
Concentration of SOD
时间窗: 8-hour after exercise
Concentration of catalase
时间窗: before exercise
Concentration of IFN-γ
时间窗: before exercise
Concentration of TBARS
时间窗: before exercise
Concentration of catalase
时间窗: immediately after exercise
Concentration of catalase
时间窗: 2-hour after exercise
Concentration of catalase
时间窗: 4-hour after exercise
Concentration of catalase
时间窗: 8-hour after exercise
Concentration of PC
时间窗: 8-hour after exercise
Concentration of SOD
时间窗: before exercise
Concentration of GPx
时间窗: before exercise
Concentration of GPx
时间窗: immediately after exercise
Concentration of GPx
时间窗: 2-hour after exercise
Concentration of GPx
时间窗: 4-hour after exercise
Concentration of CK
时间窗: 2-hour after exercise
Concentration of GPx
时间窗: 8-hour after exercise
Concentration of CK
时间窗: before exercise
Concentration of CK
时间窗: immediately after exercise
Concentration of LDH
时间窗: immediately after exercise
Concentration of LDH
时间窗: 2-hour after exercise
Concentration of LDH
时间窗: 4-hour after exercise
Concentration of LDH
时间窗: 8-hour after exercise
Concentration of IL-6
时间窗: before exercise
Concentration of IL-6
时间窗: immediately after exercise
Concentration of IL-6
时间窗: 2-hour after exercise
Concentration of IL-6
时间窗: 4-hour after exercise
Concentration of CK
时间窗: 4-hour after exercise
Concentration of CK
时间窗: 8-hour after exercise
Concentration of LDH
时间窗: before exercise
Concentration of IL-6
时间窗: 8-hour after exercise
Concentration of CRP
时间窗: before exercise
Concentration of CRP
时间窗: immediately after exercise
Concentration of CRP
时间窗: 2-hour after exercise
Concentration of CRP
时间窗: 4-hour after exercise
Concentration of CRP
时间窗: 8-hour after exercise
Concentration of eosinophil
时间窗: 2-hour after exercise
Concentration of eosinophil
时间窗: 4-hour after exercise
Concentration of eosinophil
时间窗: immediately after exercise
次要结局
未报告次要终点