Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Growth hormone and insulin signal pathways
研究概览
简要总结
Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.
Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.
In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy men
- •Body mass index (BMI) 20-26
- •age 18-45 years
排除标准
- •any kind of disease
- •any use of medicine
研究组 & 干预措施
Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
干预措施: Exercise (Other)
Fasting
3 days of fasting and then the same as arm 1
干预措施: Fasting (Other)
Control
control: muscle and fat biopsies and basal aminoacid and glucose turnover
结局指标
主要结局
Growth hormone and insulin signal pathways
时间窗: 30 min
次要结局
- aminoacid and glucose turnover(4 hours)