NL-OMON34949撤回3 期
D-cycloserine (DCS) enhancement of exposure and response prevention (ERP) therapy in panic disorder with agoraphobia: a randomized controlled trial. - D-cycloserine enhancement of exposure and ERP
适应症
试验速览
- 阶段
- 3 期
- 状态
- 撤回
- 入组人数
- 72
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Adults patients (between 18 and 55 years) with panic disorder + agoraphobia (PD+AGO), according to DSM-IV diagnoses as established using standardized interviews. And are referred to the outpatient clinic of one of the participating centres.
排除标准
- •Patients with :
- •- co-morbided psychiatric disorders (severe major depressive disorder, bipolar disorder, psychosis, dependence and abuse of alcohol, drugs in the past three months)
- •- mental deficiency
- •- inability to adequately read or speak Dutch
- •- (a history of) neurological disease (i.e. neurovascular disease, movement disorders, seizures, dementia), renal or liver abnormalities, and a history of allergies, adverse reactions or rash on medication.
- •- Currently taking benzodiazepines, since benzodiazepine might hamper therapy effect.
- •- Pregnancy or breastfeeding at the time of the study
- •- use of isoniazide and cycloserines.
- •- use of variable dosages of antidepressiva (SSRI*s of TCA)( the use of a fixed dosage of antidepressiva is NOT an exclusion criterium)
- •- An evidence based behavioural therapy for panic disorder during the past 12 month.
研究者
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D-CYCLOSERINE ENHANCEMENT OF EXPOSURE TREATMENT OF DENTALLY FEARFUL AND AVOIDANT CHILDREN. A PILOT STUDYAvoidance of dental care because of dental anxiety often result in reduced dental health and need for sedation or treatment in general anesthesia. Treatment of dental anxiety is time consuming and not given priority. D-cycloserine has shown to increase the effectiveness of the anxiety/ phobia treatment among adults, but needs to be tested among younger age groups. A medication that will enhance the effect of the anxiety treatment would be of great advantage for the fearful young patient.EUCTR2010-019712-20-NOniversity of Oslo, Institute of Clinical Dentistry