comparative study of dexmedetomidine and buprenorphine as adjuvants to postoperative epidural bupivacine for analgesia in lower limb joint replacement surgeries.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- To compare onset, duration, quality of postoperative analgesia of epidurally administered bupivacaine with dexmedetomidine and bupivacaine with buorenorphine
研究概览
简要总结
epidural anesthesia is the most commonly used technique for providing not only intraoperative surgical anesthesia but also postoperative analgesia in lower abdominal and lower limb surgeries. early postoperative mobilization and rehabilitation with minimally associated pain and discomfort is the most desirable feature in modern orthopedic surgery. epidural analgesia also obtunds cental sensitizationn and pain induced organ dysfunction, leading to improved outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA 1 & 2 2)PATIENTS UNDERGOING TOTAL KNEE AND HIP REPLACEMENT SURGERIES 3)Uneventful intraoperative patients.
排除标准
- •ASA 3 & 4 2)ALLERGY TO LOCAL ANESTHETICS, DEXMEDETOMIDINE AND BUPRENORPHINE 3) BLEEDING AND NEUROMUSCULAR DISORDERS.
结局指标
主要结局
To compare onset, duration, quality of postoperative analgesia of epidurally administered bupivacaine with dexmedetomidine and bupivacaine with buorenorphine
时间窗: To compare onset, duration, quality of postoperative analgesia of epidurally administered bupivacaine with dexmedetomidine and bupivacaine with buorenorphine
次要结局
- assess and compare the haemodynamic parameters, side effects and time for ambulation(after giving epidural topup onset of analgesia, sedation, duration of analgesia, haemodynamic parameters, mobilization time)