NCT04511858已完成不适用
Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Maximum level of voluntary activation of relative central fatigue
研究概览
简要总结
The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is an especially useful model for documenting the origins of central fatigue. This protocol will compare fatigue during and after ultra-endurance exercise bouts that result in moderate lower-limb tissue damage (i.e. cycling) or significant damage (i.e. running). The results of this protocol will allow us to further understanding of the reasons for major central fatigue, i.e. within the central nervous system, in ultra-endurance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Specialist in endurance and ultra-endurance. in the 2 disciplines: running and cycling (triathletes, duathletes or trailers achieving at least 30% of their training volume in cycling), and having at least finished one long distance event in the last 2 years,
- •Affiliated or beneficiary of a social security scheme.
- •Signature of the consent form
排除标准
- •Any subject who has been injured in the 3 months prior to the protocol
- •Anyone with chronic joint pathologies (e.g.: repetitive sprains, patellar or ligament problems).
- •Any subject with chronic or central neurological pathologies
- •Any subject with a contraindication to magnetic stimulation
- •Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) on the study.
- •Contraindication to the application of a magnetic field:
- •Heart or respiratory insufficiency.
- •Subject with a cardiac pace maker.
- •Cardiac valve wear and serious cardiovascular diseases.
- •Presence of prosthetic material or ferromagnetic foreign bodies in the head.
- •Presence of cochlear implants or ocular prosthetic material.
- •History of neurosurgical interventions.
- •Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
- •History of comitiality, contralateral knee disease or musculoskeletal disease.
- •Any subject participating at the same time in another interventional experiment requiring physical exercise.
- •Any subject who has taken corticosteroids within 3 months (inhalation, infiltration or history of prolonged corticosteroid therapy).
- •Any subject under guardianship or curatorship
结局指标
主要结局
Maximum level of voluntary activation of relative central fatigue
时间窗: Before and immediately after 5h exercise
measured in isometric mode of the knee extensors, between the value before and immediately after a 5-hour cycling or running event at the same relative intensity
次要结局
- Maximum level of voluntary activation of fatigue centrale absolute(Before and immediately after 5h exercise)
- Cortical excitability(Before and immediately after 5h exercise)
- Measurement of isometric force values(Before and immediately after 5h exercise)
- Platelets(Before and immediately after 5h exercise)
- Hemoglobin(Before and immediately after 5h exercise)
- C-reactive protein(Before and immediately after 5h exercise)
- Maximum level of voluntary activation with electrical evoked activation(Before and immediately after 5h exercise)
- Spinal excitability(Before and immediately after 5h exercise)
- Red blood cells(Before and immediately after 5h exercise)
- Measurement of the time maintained at the speed corresponding to the 2nd ventilatory threshold(Before and immediately after 5h exercise)
- Corticospinal excitability(Before and immediately after 5h exercise)
- Measurement of speed, force and power values(Before and immediately after 5h exercise)
- Mean corpuscular hemoglobin concentration(Before and immediately after 5h exercise)
- Creatine PhosphoKinase(Before and immediately after 5h exercise)
- Interleukines(Before and immediately after 5h exercise)
- White blood cells(Before and immediately after 5h exercise)
- Lactate(Before and immediately after 5h exercise)
- measurement of the time maintained at the power corresponding to the 2nd ventilatory threshold(Before and immediately after 5h exercise)
研究者
研究点 (2)
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