The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of Postoperative Nausea and Vomiting in the Women Patients Undergoing Thyroidectomy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- incidence of postoperative nausea and vomiting
研究概览
简要总结
The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may increase patient discomfort, delay patient discharge, and increase the cost of patient care, the risk of postoperative bleeding which may potentially cause airway obstruction.
It is reported that the maintenance of anesthesia with propofol-remifentanil or sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone, but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3 antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly during this period.
The purpose of this study was to evaluate and compare the incidence of PONV after thyroidectomy with three different anesthetic methods, sevoflurane or sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients undergoing thyroidectomy euthyroid status American Society of Anesthesiology Physical status 1,2
排除标准
- •Ideal body weight >130% gastrointestinal disease prior administration of anti-emetics (24hr)
研究组 & 干预措施
Sevoflurane, remifentanil, propofol, and palonosetron
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction.
干预措施: sevoflurane (Drug)
Sevoflurane
anesthesia induction with pentothal sodium (4-5 mg/kg), maintenance with sevoflurane(1.6-2.5 vol%)
干预措施: sevoflurane (Drug)
Sevoflurane
anesthesia induction with pentothal sodium (4-5 mg/kg), maintenance with sevoflurane(1.6-2.5 vol%)
干预措施: pentothal sodium (Drug)
sevoflurane, remifentanil, and propofol
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%)
干预措施: sevoflurane (Drug)
sevoflurane, remifentanil, and propofol
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%)
干预措施: remifentanil (Drug)
sevoflurane, remifentanil, and propofol
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%)
干预措施: propofol (Drug)
Sevoflurane, remifentanil, propofol, and palonosetron
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction.
干预措施: Palonosetron (Drug)
Sevoflurane, remifentanil, propofol, and palonosetron
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction.
干预措施: remifentanil (Drug)
Sevoflurane, remifentanil, propofol, and palonosetron
anesthesia induction and maintenance with remifentanil, propofol and sevoflurane(1.6-2.5 vol%), and palonosetron 75 ug administration prior to anesthesia induction.
干预措施: propofol (Drug)
结局指标
主要结局
incidence of postoperative nausea and vomiting
时间窗: 24 hour postoperative
次要结局
- incidence of postoperative nausea and vomiting(48 hour postoperative)
研究者
DAE HEE KIM
Assistant Professor
Ajou University School of Medicine