Predictive Factors for the Benefit of Stereotactic Body Radiotherapy for Oligometastatic Lymph Node Recurrence in Prostate Cancer: a Single Institution Experience
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- time to biochemical recurrence
研究概览
简要总结
Single-institution retrospective analysis for predictive factors of prostate cancer patients presenting with isolated or limited lymph node (LN) recurrence (1-3 lesions) on F-Ccholine PET-CT (CholPET) treated with SBRT between January 2010 and July 2015.
详细描述
Single-institution retrospective analysis of consecutive prostate cancer patients after definitive primary treatment, without local recurrence, presenting with isolated or limited lymph node (LN) recurrence (1-3 lesions) on F-Ccholine PET-CT (CholPET) treated with SBRT between January 2010 and July 2015.
Endpoints of interest are biochemical response rate (defined as a reduction by at least 10% of the initial PSA value), time to biochemical recurrence (TBR) (defined as the time interval from SBRT until second PSA rise), and time interval between SBRT and ADT start. Univariate analysis is used to identify prognostic factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •histologically proven diagnosis of prostate cancer
- •Radical prostatectomy (± salvage radiotherapy)
- •PSA relapse (defined by two consecutive rising PSA values >0.2 ug/l)
- •one to three lymphnodes positive on Choline-PET
- •no recurrence in prostatic bed on Choline-PET
- •WHO performance status of 0-1
- •no previous chemotherapy or ADT for prostate cancer.
排除标准
- •primary treatment for prostate cancer by RT or brachytherapy
- •bone (M1b) metastases
- •visceral (M1c) metastases
- •any symptomatic nodal lesion
结局指标
主要结局
time to biochemical recurrence
时间窗: 18 months
time interval from SBRT until second PSA rise
次要结局
- biochemical response rate(18 months)
- time interval between SBRT and ADT start(18 months)