Multimodal Neural Investigation of Reward Processing in Mental Illness

University of California, San Francisco2 个研究点分布在 1 个国家目标入组 80 人开始时间: 2013年10月1日最近更新: 2026年9月14日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: University of California, San Francisco
入组人数: 80
试验地点: 2
主要终点: EEG

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to examine the nature of reward processing dysfunctions in schizophrenia using neuroimaging techniques that capture in vivo brain functioning, such as EEG and fMRI.

详细描述

This experiment takes place over the course of two or three days. On each visit day, the experiment will involve a brief interview session, electroencephalography (EEG) recording,and/or a magnetic resonance imaging (MRI).

Screening tests or procedures include:

If you are female of child bearing potential, you must complete a urine pregnancy test for the MRI procedure
You will be asked a series of questions about your mental health and your background

If the screening exam shows that you can be in the main part of the study and you choose to continue, these are the tests and procedures that you would complete on one or two test days:

EEG recording: In this procedure, the researcher will assess your brain function while you perform simple computer-based tasks. The computer tasks involve presentation of pictures to which you respond by pressing a button. You will be given clear instructions and a chance to practice before each task. While you are performing these tasks, we will record the weak electrical signals produced by your brain, or "brain waves", using a technique called electroencephalography (EEG).

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Cross Sectional

入排标准

年龄范围: 18 Years 至 30 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•The subject population will include 18 to 30 year old participants of any gender, race, and ethnicity. All subjects will be able to speak and understand English.
•Schizophrenia subjects:
•1. Patients must be diagnosed with DSM-IV schizophrenia, schizophreniform, or schizoaffective disorder based on a SCID-P interview.
•Depression subjects:
•1. Patients must be diagnosed with DSM-V Major Depressive Disorder based on a SCID-P interview.
•Post Traumatic Stress Disorder subjects:
•1. Patients must be diagnosed with DSM-V Post Traumatic Stress Disorder based on a SCID-P interview.
•Gambling Disorder subjects:
•1. Patients must be diagnosed with DSM-V Gambling Disorder based on a SCID-P interview.
•Comparison subjects:
•1. Control participants must not have past or present Axis I diagnosis as determined by the SCID-NP.

排除标准

•All subjects:
•A hearing deficit greater than 40dB in both ears detected during the hearing test
•Substance dependence, as per clinical judgment, in the past 1 year (except caffeine and nicotine)
•A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic or neurological
•History of head injury with loss of consciousness greater than 15 minutes
•Any other condition or medication, which in the opinion of the investigator would preclude participation in the study.
•Non-English speaking.
•Comparison subjects:
•1. Any first-degree relative with schizophrenia or bipolar disorder.

研究组 & 干预措施

Healthy Controls

Individuals who have not met criteria for a psychiatric, mood, or gambling disorder within their lifetime according to our research criteria for symptoms indicative of a psychiatric, mood, or gambling disorder.