Loco-regional Treatment for HCC Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 主要终点
- Radiological Response ( complete / partial / tumour progression)in the Radiology (CT/ MRI) before transplantation
研究概览
简要总结
This study aimed to analyze the outcomes of loco-regional treatment prior Living Donor Liver Transplantation in patients with HCC.
详细描述
50 patients received LDLT at Ain Shams Centre for Organ Transplantation (ASCOT) over 1 year of whom data of 29 HCC patients were analyzed. Twenty patients met the Milan criteria (68.97%) & 4 (13.8%) were beyond Milan but met UCSF criteria and 5 were exceeding UCSF criteria (17.2%).All patients underwent preoperative LRTs, The protocol of bridging/down staging, methods, duration of follow up, the number of the patients who were successfully down-staged before LT and their outcomes after LT were recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients 18-65 years
- •Patients transplanted for HCC within Milan and UCSF criteria who underwent pre transplant bridge or down staging treatment for HCC
排除标准
- •Tumor progression on the waiting list
- •Vascular invasion by imaging studies
- •Extrahepatic or lymph node metastasis
结局指标
主要结局
Radiological Response ( complete / partial / tumour progression)in the Radiology (CT/ MRI) before transplantation
时间窗: 3 months
the success of loco-regional therapy for hepatocellular carcinoma in term of radiological complete or partial response in the last spiral triphasic abdominal CT and /or MRI before transpalantation
次要结局
- the degree of accuracy between the last CT/ MRI and the pathology of explant in term of number , size and ablation (complete necrosis ) for HCC(3 months)
研究者
Iman Fawzy Montasser
Associate profesor of tropical medicine , Ain Shams university
Ain Shams University