NCT00123214已完成不适用
Pilot Study: A Dietary Intervention May Decrease the Negative Metabolic and Cognitive Consequences of Chronic Sleep Deprivation
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Resting Metabolic Rate
研究概览
简要总结
The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.
详细描述
This pilot study included 18 medical residents at two academic medical centers in New York City. All residents who participated in the study were assigned to work a night shift schedule for two weeks, and began the study on the morning prior to their first evening shift. The study subjects were randomly assigned to one of two groups:
- Intervention diet -- consisting of 40% carbohydrates, 30% protein, and 30% fat with 2.4g of long chain fatty acid supplements (n=9) Total calories for males was 1600/day, and 1200/day for females
- Control group -- ad lib diet.
Main outcome measures included:
- weight
- resting metabolic rate
- percent body fat
- lipid profile
- CRP
- fasting glucose and insulin levels
- urinary neurotransmitter levels
- salivary cortisol
- six cognitive tests of memory, attention, and executive function.
Subjects were tested on day 1, 7, and 14 of the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single
入排标准
- 年龄范围
- 25 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Medical resident in good standing at Cabrini Medical Center or Saint Vincent's Hospital, NY.
- •Must be scheduled for two consecutive weeks of night shift work.
排除标准
- •Febrile illness
- •Food allergies of any kind
- •Taking any prescription medication
- •History of diabetes or thyroid dysfunction
- •Body mass index (BMI)>30
- •Pregnancy
结局指标
主要结局
Resting Metabolic Rate
次要结局
- Weight
- Percent Body Fat
- Waist Circumference
- Lipid Profile
- C-reactive Protein Levels
- Fasting serum glucose
- Fasting serum insulin
- Urinary neurotransmitter levels
- Salivary a.m. cortisol levels
- Cognitive scores on: Stroop Test, Hopkins Verbal Learning Test, Trail Making Test, Digit Span, Block Design, Dynamic Visual Acuity, Short Form 36
研究者
研究点 (1)
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