The Effects of Palm Olein and Palm Kernel Oil Diets on Gut Hormones and Appetite in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Glucose-dependent Insulinotropic Polypeptide (GIP)
研究概览
简要总结
The goal of this clinical trial is to investigate the postprandial effect of palm olein- and palm kernel oil- diets compared to PUFA-rich diet (sunflower oil in this study) on gut hormones response and appetite in healthy adults. The main questions it aims to answer are:
• Do palm olein- and palm kernel oil-diets postulate to improve satiety and lower appetite compared to PUFA rich diet (sunflower oil) in healthy adults? Researchers will compare diets prepared with palm olain or palm kernel oil to a diet prepared with sunflower oil to see the effects of these three diets on gut hormones and satiety score.
Participants will:
- Attend a health screening session for subjects selection according to inclusion and exclusion criteria.
- Visit the study center three times with 2 weeks apart.
- Provide blood samples and fill up questionnaires at different time point within 4 hours.
- Receive a ad libitum meal after 4 hours intervention.
详细描述
Please refer to the protocol uploaded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 20 to 45 years.
- •BMI 20 to 27.5 kg/m
- •Blood pressure with 90 to 130 mmHg for systolic and 60 to 80 mmHg for diastolic measurements.
- •Fasting blood glucose of 3.9 to 5.5 mmol/L.
- •Fasting total cholesterol < 6.0 mmol/L.
- •Fasting triglycerides < 2.3 mmol/L.
- •Not using any form of nicotine and alcohol.
排除标准
- •Diagnosed any form of heart disease, hypertension, diabetes mellitus, and metabolic syndrome with or without medication.
- •Consuming any long term prescribed medications or supplements, including hormonal contraceptive pills.
- •Having moderate anaemia with haemoglobin <110 g/l for men and <100 g/l for women.
- •Having blood clotting problem
- •Having difficulty in cannulation (small, thin or hard-to-find veins)
- •Women who are pregnant or lactating.
研究组 & 干预措施
T
SFO-PO-PKO
干预措施: Sunflower Oil (Other)
P
PO-PKO-SFO
干预措施: Sunflower Oil (Other)
Q
PO-SFO-PKO
干预措施: Sunflower Oil (Other)
R
PKO-PO-SFO
干预措施: Sunflower Oil (Other)
S
PKO-SFO-PO
干预措施: Sunflower Oil (Other)
U
SFO-PKO-PO
干预措施: Sunflower Oil (Other)
P
PO-PKO-SFO
干预措施: Palm olein (Other)
P
PO-PKO-SFO
干预措施: Palm kernel oil (Other)
Q
PO-SFO-PKO
干预措施: Palm olein (Other)
Q
PO-SFO-PKO
干预措施: Palm kernel oil (Other)
R
PKO-PO-SFO
干预措施: Palm olein (Other)
R
PKO-PO-SFO
干预措施: Palm kernel oil (Other)
S
PKO-SFO-PO
干预措施: Palm olein (Other)
S
PKO-SFO-PO
干预措施: Palm kernel oil (Other)
T
SFO-PO-PKO
干预措施: Palm olein (Other)
T
SFO-PO-PKO
干预措施: Palm kernel oil (Other)
U
SFO-PKO-PO
干预措施: Palm olein (Other)
U
SFO-PKO-PO
干预措施: Palm kernel oil (Other)
结局指标
主要结局
Glucose-dependent Insulinotropic Polypeptide (GIP)
时间窗: postprandial from baseline (0 min) to 4 hours
GIP analysed using ELISA kits using plasma sample.
次要结局
- Glucagon-like Peptide 1 (GLP-1)(Postprandial from baseline (0 min) to 4 hours)
- Peptide YY (PYY)(Postprandial from baseline (0 min) to 4 hours)
- Ghrelin(Postprandial from baseline (0 min) to 4 hours)
- HOMA IR(Postprandial from baseline (0 min) up to 2 hours.)
- Cholecytokinin, CCK(Postprandial from baseline (0 min) to 4 hours.)