Temporal Variation of the Exposure to Pesticides in the Employees of the Limoges University Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- glyphosate overconsumption
研究概览
简要总结
In a sample of 300 employees of the Limoges University Hospital, it is proposed to explore the intraindividual and interindividual variability of urinary concentrations of glyphosate and 320 other pesticides. The employees will fill a questionary in which will allow to explore the relationships between the concentrations, lifestyle and dietary habits.
详细描述
The general population is exposed to pesticides through the ingestion of food and water. The presence of pesticides in human urine has been demonstrated in numerous studies. Conventionally, biological monitoring studies use an undifferentiated urine sample or the first morning urine. The reliability of measuring a single-point urinary concentration to represent the profile of pesticide exposure in individuals over time is, however, questionable. Rare studies reporting intra-individual outcomes of pesticide exposure have been conducted in specific populations, such as children and pregnant women.
It is proposed to carry out a descriptive biomonitoring study of the urinary concentration of approximately 320 pesticides in a sample of the general population. Among these, the study will focus on glyphosate.
The originality of our study is:
- (i) Exploration of exposure to the main pesticides in a sample of 300 people by measuring urinary concentration by specific and sensitive methods of LC-MS/MS and GC-MS/MS; These 300 subjects will be hospital staff of the Limoges University Hospital.
- (ii) Exploration of the intra-individual variability of exposure by repeating measurements in urine samples taken over a 24-hour period and/or several times over the course of a week;
- (iii) Determination of the frequency of subjects who have potentially been exposed to doses higher than the acceptable daily intake (in particular for glyphosate) (iv) The association of these exposure values with data from a self-administered questionnaire in order to identify the determinants of this exposure
- (V) Estimating the predictability/reliability of a single urine sample to represent this exposure of individuals/populations over time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult 18 years and over.
- •Employed by the University Hospital of Limoges.
- •Having consented to participate in the study after being informed.
排除标准
- •Adult with a professional activity during which he is required to handle or come into contact with glyphosate
结局指标
主要结局
glyphosate overconsumption
时间窗: 1 week
Proportion of individuals with an estimated daily consumption of glyphosate greater than the acceptable daily intake of glyphosate
次要结局
- Coefficient of variation of the glyphosate concentrations(1 week)
- Intra-individual variability of urinary glyphosate concentrations(1 week)
- Impact of urine sample collection schedule on glyphosate concentration measurement(1 week)
- Intra-individual variability of urinary 320 pesticides concentrations(1 week)
- Impact of urine sample collection schedule on 320 pesticides concentration measurement(1 week)
- Identification of determinant of exposure to glyphosate(1 week)
- Identification of determinants of exposure to a panel of around 320 pesticides(1 week)