Locoregional Recurrence After Radiotherapy in Breast Cancer Patients Based on Molecular Subtypes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 265
- 主要终点
- Determine Local & regional recurrence according to different molecular subtypes.
研究概览
简要总结
our study will be retrospective on breast cancer patients to detect relation between the locoregional recurrence of breast cancer after radiotherapy and the molecular subtypes
详细描述
Having replaced lung cancer as the most common cancer globally, breast cancer today represent 1 in 8 cancer cases and a total of 2.3 million new cases in both sexes .
It Represents a quarter of all cancer cases in females, and it was the most commonly diagnosed cancer in women in 2020 , its burden has been growing in many parts of the world, particularly in transitioning countries . An estimated 685,000 women died from breast cancer in 2020, corresponding to 16% or 1 in every 6 cancer deaths in women.
In Egypt, it constitutes 33% of female cancer cases and more than 22,000 new cases diagnosed each year .
Treatment Strategies include Surgery, Chemotherapy ,Radiotherapy, Endocrinal (Hormonal) Therapy & Biological Therapy , according to stages and molecular subtypes
A majority of breast cancer patients undergoing surgical excision will receive radiotherapy as a local treatment, which will reduce local and regional recurrence (LRR), further elevating survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female
- •Histological proven breast cancer (IDC / ILC)
- •with known receptor status
- •Patient did mastectomy or breast conservative surgery +/- lymph node dissection .
- •received radiotherapy
- •on regular follow up
排除标准
- •Metastatic from the start (stage 4)
结局指标
主要结局
Determine Local & regional recurrence according to different molecular subtypes.
时间窗: within 5 years from diagnosis
radiologically or with re biopsy
- 5-year free survival
时间窗: within 5 years from diagnosis
radiologically
次要结局
- Metastasis-Free Survival(within 5 years from diagnosis)
研究者
Amira Ali Fekry Mohamed
Assistant lecturer
Assiut University