Low-load Blood Flow Restriction Training in COPD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Knee extensor strength
研究概览
简要总结
Peripheral muscle weakness is a predominant problem in patients with COPD and treated using exercise training in pulmonary rehabilitation. Despite pulmonary rehabilitation being an effective intervention, muscle strength impairment is a persisting problem in COPD patients. Patients have problems to tolerate the high training loads, which are necessary to develop strength. Low-load blood flow restriction training (LL-BFRT) might therefore be an option to enhance muscular response of patients with COPD to strength training. Up to now, no studies investigating LL-BFRT in respiratory diseases are available.
The primary outcome of this randomized pilot study is knee extensor muscle strength. Secondary, the study will evaluate if LL-BFRT is well tolerated and feasible in COPD patients attending outpatient pulmonary rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed COPD according to GOLD-guidelines
- •Assigned to outpatient pulmonary rehabilitation by the treating physician
排除标准
- •Physical or intellectual impairment precluding informed consent or protocol adherence
- •Non-German speaking (precluding informed consent)
- •Acute or recent (within the last 6 weeks) exacerbation of COPD
- •Attending a pulmonary rehabilitation program within the last 3 months
- •Pregnant patients
- •History of thromboembolic event in the lower extremity
- •Diagnosis of polyneuropathy
- •Resting systolic blood pressure <100 mmHg
结局指标
主要结局
Knee extensor strength
时间窗: during 12 weeks (24 exercise sessions)
Between-group difference in total change in isometric muscle strength of the knee extensor muscles, measured by handheld dynamometry in newtonmeter
次要结局
未报告次要终点