NCT01306149已完成不适用
Natural History of Biochemical Parameters of Mineral Metabolism and Protein-bound Uremic Retention Molecules in Incident Peritoneal Dialysis Patients: a Longitudinal Observational Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- natural history of clearances and serum parameters of mineral metabolism and protein-bound toxins
研究概览
简要总结
The aims of this study are
- To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules', and protein bound URM in incident peritoneal dialysis (PD) patients.
- To evaluate the natural history and determinants of the generation rate of URM originating from bacterial protein fermentation in PD patients.
- To evaluate the natural history of biochemical parameters of mineral metabolism in incident PD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Incident PD patients, defined as patients who started on PD as first renal replacement therapy less than 8 weeks before inclusion
- •written informed consent
- •age > 18 years old
排除标准
- 未提供
结局指标
主要结局
natural history of clearances and serum parameters of mineral metabolism and protein-bound toxins
时间窗: 15 years
To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules, and protein bound URM in incident peritoneal dialysis (PD) patients.
次要结局
- determinants of generation rate of uremic retention solutes(15 years on average)
研究者
Björn Meijers
Dr.
Universitaire Ziekenhuizen KU Leuven
研究点 (1)
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