The Effects of chaNging LIGHT Levels on Contrast sENsitivity in Patients With Glaucoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 115
- 试验地点
- 1
- 主要终点
- vision-related quality of life in patients with glaucoma
研究概览
简要总结
The study is a prospective observational study where participants will be recruited from the Ophthalmology department (Outpatient department, Eye Casualty). Only one research visit will be required. Participants will be asked to fill in a set of questionnaires (Visual Functioning Questionnaire-15(61), Low Luminance Questionnaire(62)) assessing their quality of life and vision and their full medical history will be collected. Then they will have their contrast sensitivity tested under various light conditions. If a recent visual field test is not available, that might be performed as part of the study.
详细描述
The purpose of our, real world study is to explore contrast sensitivity differences after changes in ambient light setting in patients with glaucoma compared with controls (patients with ocular hypertension). Participants will be asked to read a Pelli- Robson chart under photopic (bright light conditions) and mesopic (intermediate light conditions); followed by scotopic conditions (dim light conditions). This chart is a fast, easy, and effective way to measure spatial contrast sensitivity with reliable and reproducible results(60). This study will therefore help clinicians gain more insight into glaucoma related disability and provide a possible additional tool to visual field testing in patients with advanced glaucoma where VF testing may be hampered by floor effects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Male or Female, aged 40 years or above.
- •Diagnosis of glaucoma (including primary open angle glaucoma, pigment dispersion syndrome, pseudoexfoliation, normal tension glaucoma, chronic angle closure glaucoma, narrow angle glaucoma) or ocular hypertension
- •Willing and able to give informed consent for participation in the study.
- •Best Corrected Visual Acuity equal or better than 6/12 as measured with the Snellen Chart
排除标准
- •• Neovascular, uveitic, acute angle closure glaucoma
- •Non-glaucomatous ocular disease such as AMD, Diabetic retinopathy, Inherited eye diseases
- •Visually significant cataracts (Distance VA ≤ 6/12 (0.30 LogMAR) and grade ≥ grade 2 nuclear sclerosis.)
- •Current use of miotic glaucoma medication
- •Incisional or laser eye surgery within 3 months of enrolment
- •Severely impaired cognition
- •Self-reported physical ability limiting function (e.g. stroke)
- •Unreliable visual fields (SITA Standard or SITA Fast: fixation losses >20% or false-positive errors >33% or false-negative errors >33%)
结局指标
主要结局
vision-related quality of life in patients with glaucoma
时间窗: 1 day study visit
assessed using the the visual functioning questionnaire - 25 questionnaire
Visual function
时间窗: through study completion, an average of 1 year
assessed using the low luminance questionnaire
次要结局
- To correlate visual impairment with contrast sensitivity results(through study completion, an average of 1 year)
- Contrast Sensitivitiy(through study completion, an average of 1 year)