TCTR20181212001尚未招募3 期
Effect of Baclofen on PPI-non-responded globus pharyngeus correlated with high-resolution manometry: a randomized double-blind placebo-controlled trial.
Faculty of Medicine, Prince of Songkla University0 个研究点目标入组 62 人开始时间: 2018年12月12日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 62
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 50 Years（—）
- 性别
- All
入选标准
- •- Age 18-50 years
- •- Persistent globus symptoms despite of 2 week double doses or high dose PPI therapy with good compliance with symptom improvement less than fifty percent from baseline 23,24
- •- No structural lesion identified on neck & nasolaryngeal examination
- •- Absence of alarming symptoms ( for example; dysphagia, odynophagia, sore throat, significant weight loss )
- •- GERD-Q score25,26 < 8
排除标准
- •-Known allergy to Baclofen
- •-Epilepsy or history of seizures
- •-Renal impairement: estimated glomerular filtration rate <60 ml/min/1.73m2
- •-Centrally modulating agents or prokinetic drugs use within 2 weeks before randomization
- •-Pregnancy or lactation
- •-Major esophageal motor disorders (achalasia, EGJ outflow obstruction, diffuse esophageal spasm, jackhammer esophagus, absent peristalsis)
研究者
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