Effects of Low Concentrations of Nitrous Oxide on Cognitive Functions and Reaction Time
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Cognitive test results
研究概览
简要总结
The aim of the study is to test the effects of low concentrations of nitrous oxide on cognitive functions and reaction time in human.
详细描述
Nitrous oxide is a widely used gas in medicine, in standard concentrations above 50%. Its favourable physical properties and easy detectability by anaesthetic gas analysors predispose nitrous oxide to become a possible "tracing gas" for leak detection in experiments in which modified breathing system are in use. In these breathing experiments, the inspired concentrations of nitrous oxide would be well below the anaesthetic/analgesic concentrations. The aim of this study is to investigate the effects of these low concentrations of nitrous oxide (5, 7, 10, 12, 15, 20 %), compared to placebo (air, 0% nitrous oxide). The cognitive functions are tested using Digit Symbol Substitution Test, Reaction Time and Visual Analogue Scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers from the Czech Technical University
排除标准
- •pregnancy
- •allergy to nitrous oxide
- •severe asthma or other severe respiratory conditions
- •severe cardiovascular conditions
研究组 & 干预措施
Intervention Group - 20% nitrous oxide
Breathing 20% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.
干预措施: Nitrous Oxide (Drug)
Control group - air
Breathing air with 21 % of oxygen (0% nitrous oxide). Performing cognitive tests as per protocol.
干预措施: Placebo - air (Other)
Intervention Group - 5% nitrous oxide
Breathing 5% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.
干预措施: Nitrous Oxide (Drug)
Intervention Group - 7% nitrous oxide
Breathing 7% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.
干预措施: Nitrous Oxide (Drug)
Intervention Group - 10% nitrous oxide
Breathing 10% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.
干预措施: Nitrous Oxide (Drug)
Intervention Group - 12% nitrous oxide
Breathing 12% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.
干预措施: Nitrous Oxide (Drug)
Intervention Group - 15% nitrous oxide
Breathing 15% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.
干预措施: Nitrous Oxide (Drug)
结局指标
主要结局
Cognitive test results
时间窗: Through study completion, an average of 1 year
The results of cognitive test performed during inhalation of defined concentration of nitrous oxide. Cognitive tests: Digit Symbol Substitution Test (DSST).
Reaction Time
时间窗: Through study completion, an average of 1 year
The results of reaction time test performed during inhalation of defined concentration of nitrous oxide. Reaction Time (in seconds) using a computer-based test.
次要结局
未报告次要终点