Effect of Cancer Treatment on Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Sperm concentration
研究概览
简要总结
Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.
详细描述
This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old, currently > 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old.
- •> 18 years old to 50 years old
- •Cancer in remission for at least 2 years
排除标准
- •Unable to ejaculate by masturbation to provide semen samples
- •Cryptorchidism, testicular cancer, history of vasectomy
- •On testosterone replacement therapy
- •Refusal to join the study
结局指标
主要结局
Sperm concentration
时间窗: up to 3 months
Sperm concentration
次要结局
- Semen parameters(up to 3 months)