NCT04247477已完成不适用
Comparison of Different Positive End-expiratory Pressure Titration Strategies Using ELectrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome : the DELTA Physiological Study
University Hospital, Angers2 个研究点 分布在 1 个国家目标入组 22 人开始时间: 2020年9月22日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Change in PaO2 (mmHg)
研究概览
简要总结
The aim of the this study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit.
Two of those strategies are based on electrical impedance tomography (EIT) monitoring.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with moderate to severe ARDS, defined by the Berlin consensus, at 12 to 48h from diagnosis
- •PaO2/FiO2 ratio < 150 mmHg
- •Patient affiliated to or beneficiary of a health care plan
- •Consent obtained from patient's SDM
排除标准
- •Pneumothorax
- •Contraindication to the insertion of a nasogastric tube with an esophageal balloon
- •Contraindication to the use of Electrical impedance tomography
- •Pregnancy, lactating or parturient woman
结局指标
主要结局
Change in PaO2 (mmHg)
时间窗: Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes
As it is a physiological study, all the outcomes will be analyzed with the same importance!
次要结局
- Expiratory and inspiratory transpulmonary pressure (cmH2O)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Regional ventilation distribution (%)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Change in PaCO2 (mmHg)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Plateau pressure (cmH2O)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Positive end expiratory pressure (cmH2O)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Overdistension and collapsus (%)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Center of ventilation (%)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- End expiratory lung volume (mL)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Blood pressure (mmHg)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Heart rate (bpm)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Cardiac output (L/min)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
- Global and regional end expiratory lung impedance changes (IU)(Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes)
研究者
研究点 (2)
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