The Effect of Upper-body High-intensity Interval Training on Postprandial Metabolic Control in Persons With Chronic Paraplegia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Postprandial triglyceride concentrations
研究概览
简要总结
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population. There is mounting evidence from the able-bodied literature that high-intensity interval training (HIIT) is more effective than moderate-intensity continuous training (MICT) at improving markers of cardiometabolic health. Before we can understand the long-term training effects of HIIT in this population, it is important to compare the acute metabolic responses to a typical mixed-macronutrient meal following both exercise modalities.
This study is recruiting adults (aged 18-65 years) with paraplegia (T2 or below) who sustained their spinal cord injury more than one-year ago. Participants will need to attend the laboratory at the University of Bath on four separate occasions, once for preliminary testing, and three times for study trials.
详细描述
The aim of this research is to determine the metabolic responses to a mixed-meal tolerance test following a bout of HIIT and MICT in persons with chronic paraplegia. The hypothesis is that HIIT and MICT will be more effective at reducing the total triglyceride responses compared to a resting control condition.
Preliminary measurements:
Preliminary testing will include anthropometric measurements of supine length, weight, waist and hip circumferences, and resting blood pressure. There will also be an assessment of resting metabolic rate, sub-maximal and maximal exercise capacity, and a HIIT familiarisation session. All of the exercise protocols will take place on an arm crank ergometer at the University of Bath.
Physical activity monitoring:
For 7 days, participants will be fitted with a physical activity monitor (Actiheart™). Participants should not make any conscious changes to their normal lifestyle habits/routines during this period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individuals with a chronic (>12 months post-injury) SCI below T2
- •Individuals who spend >75% of their waking day in a wheelchair
- •Weight stable (weight not changed by >3% over the last 3 months)
排除标准
- •Individuals who an acute (<12 months post-injury) SCI
- •Individuals who spend <75% of their waking day in a wheelchair
- •Individuals on type-2 diabetes medication
- •Individuals with a peanut allergy
- •Individuals who self-report use of lipid-lowering agents
- •Individuals self-reporting active medical issues (pressure sores, urinary tract infections, cardiac disorders, musculoskeletal complaints of the upper extremities, or cardiovascular contraindications to exercise testing)
- •Individuals who report uncontrolled or regular autonomic dysreflexia
研究组 & 干预措施
Control
No exercise - 30-min of rest
High-intensity interval training
8 x 60 s intervals at 70% peak power output (intersperesed with 60 s recovery intervals at 10% peak power output)
干预措施: Exercise (Other)
Moderate-intensity continous training
25 min at 45% peak power output
干预措施: Exercise (Other)
结局指标
主要结局
Postprandial triglyceride concentrations
时间窗: 6 hours
Postprandial triglyceride concentrations in serum samples
次要结局
- Postprandial glucose concentrations(6 hours)
- Postprandial insulin concentrations(6 hours)
- Postprandial non-esterified fatty acid concentrations(6 hours)
- Postprandial substrate oxidation(6 hours)
- Rating of Perceived Exertion(MICT: End of Warm-Up, 6 minutes 15 seconds, 12 minutes 30 seconds, 18 minutes 45 seconds, End of Exercise. HIIT: End of Warm-Up, 8 minutes, 12 minutes, 16 minutes, 20 minutes))
- Heart Rate(MICT: End of Warm-Up, 6 minutes 15 seconds, 12 minutes 30 seconds, 18 minutes 45 seconds, End of Exercise. HIIT: End of Warm-Up, 8 minutes, 12 minutes, 16 minutes, 20 minutes))
- Affect(MICT: End of Warm-Up, 6 minutes 15 seconds, 12 minutes 30 seconds, 18 minutes 45 seconds, End of Exercise. HIIT: End of Warm-Up, 8 minutes, 12 minutes, 16 minutes, 20 minutes))
- Exercise Enjoyment(30 minutes post-exercise)
- Self-efficacy(30-minutes post-exercise)
研究者
James Bilzon
Professor
University of Bath