Association Between Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients: A Prospective Longitudinal Data Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4,417
- 试验地点
- 1
- 主要终点
- The primary outcome was one-year all-cause mortality.
研究概览
简要总结
Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. This study aimed to characterize postoperative frailty trajectories in older patients and to examine their association with one-year mortality, as well as factors influencing trajectory group.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged ≥65 years;
- •Underwent elective non-cardiac, non-neurosurgical procedures;
- •Completed standardized frailty assessments both preoperatively and postoperatively.
排除标准
- •Severe dementia, language disorders, significant hearing or visual impairments, or coma;
- •Cognitive function below the Mini-Mental State Examination (MMSE) thresholds (<18 for illiterate individuals, <21 for individuals with primary education, and <25 for individuals with secondary education or higher);
- •Surgery performed under local anesthesia or monitored anesthesia care;
- •Surgical duration ≤30 minutes;
- •Missing data on postoperative complications or one-year mortality required for this study;
- •Incomplete frailty assessments at 1, 3, and 6 months after surgery.
研究组 & 干预措施
A retrospective cohort study based on prospectively collected data.
Patients' frailty was assessed using the FRAIL scale at four time points: preoperatively and at 1, 3, and 6 months postoperatively. Patients were classified into distinct frailty trajectory groups using latent class trajectory modeling. The study examined the associations between frailty trajectories and one-year mortality and further identified independent factors associated with frailty trajectory membership.
结局指标
主要结局
The primary outcome was one-year all-cause mortality.
时间窗: At the one-year postoperative follow-up.
The primary outcome was one-year all-cause mortality, determined through structured telephone follow-up.
次要结局
未报告次要终点
研究者
Yanhong Liu
Deputy Chief of administration, Anesthesiology
Chinese PLA General Hospital