Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations: A Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Oxygenation
研究概览
简要总结
The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients
详细描述
The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Morbid obese (body mass index > 40) with documented restrictive lung disease scheduled to bariatric operation.
排除标准
- •Heart failure
- •ِِِِArrhythmia
- •Heart block
- •Severe liver or kidney impairment.
研究组 & 干预措施
Dexmedetomidine group
Patients will receive either, Dexmedetomidine (Precedex, Hospira, Lake forest, IL, USA) in a dose of (1ug/Kg LBW) bolus followed by 0.5ug/Kg continuous infusion for one hour
干预措施: Dexmedetomidine (Drug)
Control group
Patients will receive normal saline
干预措施: Normal saline (Drug)
结局指标
主要结局
Oxygenation
时间窗: 2 hours
assessed by P/F ratio
次要结局
- Lung mechanics(2 hours)
- arterial blood pressure(2 hours)
- plateau airway pressure(2 hours)
- heart rate(2 hours)
研究者
Ahmed Hasanin
Lecturer of anesthesia and critical care medicine
Cairo University