Effects of Dexmedetomidine on Oxygenation Index, Respiratory Index and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- The Respiratory Index
研究概览
简要总结
The purpose of this study is to investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and inflammatory factors, and to explore the protective effect of the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.
详细描述
Obstructive sleep apnea syndrome is common among people, especially among obese people, Which is characterized by periodic or complete upper airway obstruction and hypoxia during sleep. Intermittent hypoxia contributes to the lung damage by increased oxidative stress, inflammation. Some researchers suggested that dexmedetomidine can inhibit inflammatory reaction and lessen the damage of respiratory function. The aim of this study is to investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and inflammatory factors, and to explore the protective effect of the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing palatopalatyngoplasty
- •ASA physical status II-III
- •Aged 18-65 years
- •BMI 18.5-30kg/m2
排除标准
- •Bradycardia
- •Atrioventricular block
- •Allergic to the drugs
- •Complicating pulmonary disease(including pulmonary infection,COPD, asthma and so on)
研究组 & 干预措施
Group D
40 patients receive a loading infusion of dexmedetomidine (1ug/kg)for 20min follow by a maintenance infusion (0.4ug/kg/h) continued until the end of the surgery
干预措施: dexmedetomidine (Drug)
Group C
40 patients receive matching placebo (normal saline)
干预措施: normal saline (Other)
结局指标
主要结局
The Respiratory Index
时间窗: Intraoperative and immediately after surgery
Arterial blood samples were sampled before anaesthesia induction and immediately after surgery for the respiratory index by using blood gas analyzer.
The Oxygenation Index
时间窗: Intraoperative and immediately after surgery
Arterial blood samples were sampled before anaesthesia induction and immediately after surgery for the oxygenation index by using blood gas analyzer.
次要结局
- Change of tumor necrosis factor-α before anesthesia and immediately after surgery(Intraoperative and immediately after surgery)
- Change of interleukin-6 before anesthesia and immediately after surgery(Intraoperative and immediately after surgery)
- Change of interleukin-10 before anesthesia and immediately after surgery(Intraoperative and immediately after surgery)