Breastfeeding and Its Impact on the Infant-caregiver Resistome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 主要终点
- Count of antimicrobial resistance genes (ARGs) in stool
研究概览
简要总结
Antimicrobial resistance genes (ARGs) are the genes that allow bacteria to survive antibiotic treatments. These genes can be found in beneficial gut microbes, and occur more frequently in infants than adults. These genes can also transmit between different bacterial species. Exclusively breastfed infants carry fewer ARGs than formula fed infants. We are trying to find out if care-givers working with exclusively breastfed infants have fewer ARGs than those working with formula fed infants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Employment at a childcare facility or home daycare at time of sampling
- •Participant works and interacts with infants under the age 6 months old, including responsibility for changing diapers
- •Participant >18 years old
排除标准
- •Participant has a history or presence of a medical condition including Ulcerative Colitis, Crohn's Disase, Inflammatory Bowel Disease, colon cancer, Celiac's disease, or other GI disordrs
- •Current priobitic use or probiotic use within the last 4 weeks
- •Participant is currently pregnant or breastfeeding
- •Participant has an infant <12 months old at home for 3 or more days per week
- •Enrollment in a clinical trial involving an invstigational drug or dvic
- •Antibiotic use within the past 3 months
- •Participant working exclusively with infants >6 months old at time of stool sample collection
结局指标
主要结局
Count of antimicrobial resistance genes (ARGs) in stool
时间窗: 2 weeks from enrollment
Count of ARGs in stool sample, and association with infant usual diet
Abundance of antimicrobial resistance genes (ARGs)
时间窗: 2 weeks from enrollment
Abundance of ARGs in stool samples from caregivers in relation to infant usual feeding practices
次要结局
- Count and diversity of antimicrobial resistance genes (ARGs) and caregiver diet(2 weeks from enrollment)
- Diversity and abundance of antimicrobial resistance genes (ARGs) and interactions(2 weeks)
- Caregiver gut microbiome(2 weeks)