NCT01946087已完成4 期
Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 79
- 试验地点
- 2
- 主要终点
- Serum levels of CK-MB and Tn-T
研究概览
简要总结
The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≥20 years with severe degenerative AS presenting concentric remodeling of the LV, who were scheduled for AVR
排除标准
- •diabetes mellitus,
- •coronary stenosis ≥70%,
- •renal failure (serum creatinine > 2.0 mg/dL),
- •upper arm peripheral vascular disease,
- •LV ejection fraction <50%
结局指标
主要结局
Serum levels of CK-MB and Tn-T
时间窗: 24-hour after surgery
次要结局
- Myocardial activation of protective signaling pathway(After taking off CPB)
研究者
研究点 (2)
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