HCV Viral Genotyping Distribution and Genetic Variation in IL28B Distributions Among the Han Ethnic Chinese in China
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 997
- 试验地点
- 1
- 主要终点
- Hepatitis C viral and host genotypes
研究概览
简要总结
The primary objective of this study is to estimate the distributions of HCV viral/human genotypes (including IL28B and inosine triphosphatase, ITPA), and HCV RNA level among ITPA gene among 1000 Han ethnic Chinese patients with HCV who are antiviral treatment naive at the time the study is conducted.
详细描述
A sample of 1000 Han ethnic Chinese male or female who are ≥ 18 years old with a recent confirmation of anti-HCV-antibody positive and HCV RNA positive but antiviral treatment naive from 28 university affiliated hospital in China. The primary objective of this study is to estimate the distributions of HCV Viral genotyping(ie, genotype 1 through 6 and their known subtypes), and host genotypes, both inosine triphosphatase (ITPA) gene, and IL28B. This study also collects other data including patients' demographic and clinical characteristics. There is no active antiviral treatments and no follow-up in this study.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •male or female
- •Han ethnic
- •≥ 18 years old
- •recent confirmation of anti-HCV-antibody positive and HCV RNA positive 30 days prior to the recruitment
- •antiviral or interferon treatment naive
排除标准
- •< 18 years old
- •not Han ethnic
- •treated by antiviral before this study
结局指标
主要结局
Hepatitis C viral and host genotypes
时间窗: Confirmation of an HCV infection 30 days prior to the recruitment
To describe the distributions of both HCV viral and host genotypes (IL28B and ITPA) among antiviral treatment naive HCV patients
次要结局
- Hepatitis C RNA levels(Confirmation of an HCV infection 30 days prior to the recruitment)
研究者
Lai Wei
Professor
Peking University People's Hospital