Root Coverage After the Use of Coronally Advanced Flap With Advanced Platelet Rich Fibrin (A- PRF) Compared With Subepithelial Connective Tissue Graft in Management of Miller Class I and II Gingival Recession. A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- root coverage
研究概览
简要总结
patients with Miller class I , II gingival recession will be divided into 2 groups (control, intervention).the control one will receive coronally advanced flap with subepithililal connective tissue graft harvested from the palate while the intervention one will have coronally advanced flap with advanced platelet rich fibrin(A-PRF).as it represent a new generation of platelet concentrate allow for better healing and root coverage results.
Null hypothesis: In patients with Miller class I and II gingival recession, there is no difference in amount of root coverage (mm) following the application of SCTG+A-PRF compared to CAF+SCTG.
详细描述
- Population (P): Patients with single Miller class I, II gingival recessions.
- Intervention (I): Coronally advanced flap (CAF) plus platelet rich fibrin (A-PRF).
- Comparator (C): Coronally advanced flap (CAF) plus subepithelial connective tissue graft (SCTG).
- Primary Outcome (O): Root coverage (mm).
- Time frame: 9 months.
- Study design: Randomized controlled clinical trial.
- Patients are to be selected from the outpatient clinic of the department of Oral Medicine and Periodontology-Cairo University
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy patients 18 years old and older both males and females.
- •Good oral hygiene after phase I therapy.
- •Miller's class I or II gingival recession.
- •Not using antibiotics, steroids, chemotherapy or other medications that may modify results of the surgery and healing.
- •Cooperative patients able and accept to come for follow up appointments
排除标准
- •Pregnant or lactating females.
- •Current Smokers.
- •Patients with any systemic disease that may affect the periodontal healing.
- •Teeth with endodontic treatment, buccal restoration or caries.
- •Patients with poor oral hygiene
研究组 & 干预措施
intervention
CAF+ APRF
干预措施: CAF + (A-PRF) (Procedure)
control
CAF+SCTG
干预措施: CAF+SCTG (Procedure)
结局指标
主要结局
root coverage
时间窗: 9 months
measured in millimeter
次要结局
- Probing depth(9 months)
- Clinical attachment level(9 months)
- Recession width(9 months)
- Gingival esthetics(9 months)
- Width of keratinized gingiva(9 months)
- Gingival thickness(9 months)
- Post-operative pain(measured daily for the first 2 weeks post- operatively.)
- Early wound healing(1,2,4 weeks post- surgical)
- Patient Satisfaction(9 months)
研究者
heba samir
assistant lecturer
Cairo University