Analysis of Cortical Excitability in Neuropathic Pain: an Electrophysiology Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Abnormal cortical excitability in motor-sensory cross-talk
研究概览
简要总结
The purpose of this study is to determine whether patients with neuropathic pain has abnormal excitability in somatosensory cortex and abnormal sensory-motor connections.
详细描述
There are several brain areas responsible for neuropathic pain reported in functional image studies, including primary sensory cortex, insula, and anterior cingulate gyrus. However, it is few informations about the functional status of these areas. Besides, the reason of the individual variability about the developement of neuropathic pain remains unknown. It is lack of satisfactory explanation about why some people developed neuropathic pain in certain diseased situation (for example, type 2 diabetes), while others do not.
We hypothesis that patients with neuropathic pain has abnormal cortical excitability and plasticity in certain brain area. Therefore developed neuropathic pain certain diseased condition while others not. Therefore, we will use multimodal electrophysiology tools,such as transcranial magnetic stimulation, peripheral nerve stimulation, and contact heat evoke potential to monitor the cortical excitability and plasticity non-invasively.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •patients with pain resulted from dysfunction of peripheral or central nervous system
- •the disorders of peripheral nerves are diagnosed by nerve conduction study, quantitative sensory test, quantification of skin innervation or contact heat evoked potentials
- •lesion of central nervous system should be confirmed by neuroimage.
排除标准
- •previous history of epilepsy, seizure disorders or major head injury
- •previous brain surgery or intracranial metalic implant
- •implanted devices as cardiac pacemaker
- •pregnant subjects
- •patient with severe cardiac or pulmonary disease who potentially cannot tolerate stress
结局指标
主要结局
Abnormal cortical excitability in motor-sensory cross-talk
时间窗: non-applicable
次要结局
- Genetic variability of neurotrophic factors between groups(non-applicable)