Innovative Methods to Reduce Emissions and Health Impacts of Deep-frying
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 主要终点
- Change in HRV
研究概览
简要总结
Cooking oil fume (COF) is a significant source of PM2.5 for poorly ventilated space indoors and in urban streets near restaurants or night markets. Modern Chinese cooking produces high concentration of COF especially from deep-frying foods and stirred frying. Emission from high-temperature frying has been classified by the IARC as Group 2A carcinogen. Cooks are at high risk of exposure to toxic compounds from cooking fumes. However, more of the COF-related studies focused on the home kitchen and less addresses the problems in the restaurants. Studying health hazards and biomarkers of cooks may provide opportunities to understand biological mechanisms and to search and test efficacy for measures to overturn such risks.
The investigators will recruit 80 cooks who handle deep-frying and stirred frying on daily basis. The 80 cooks will be randomized to 4 groups: (1) control, (2) vegetable and fruits extract (V&F) group, (3) fish oil group, and (4) V&F-fish oil group will be provided to the participants for 2 months V&F capsules (equivalent to 4 servings a day) and fish oil capsules (1~1.5 serving a day) and placebos of the same appearance. Heart rate variability (HRV), pulmonary functions, bio-markers, oxylipins and metabolomics profile will be measured as outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Exclusion Criteria:
- •Acute diseases in the past 2 weeks
- •Taking anti-oxidant supplements in the past month
- •Taking steroid or non-steroidal anti-inflammatory drugs (such as Aspirin and Panadol) in the past week
- •Under hormone replacement therapy
- •Cancer and other severe diseases
排除标准
- •Acute diseases in the past 2 weeks
- •Taking anti-oxidant supplements in the past month
- •Taking steroid or non-steroidal anti-inflammatory drugs (such as Aspirin and Panadol) in the past week
- •Under hormone replacement therapy
- •Cancer and other severe diseases
结局指标
主要结局
Change in HRV
时间窗: baseline and 2 months later
Change in heart rate variability (HRV)
Change in pulmonary functions (TLC)
时间窗: baseline and 2 months later
Change in TLC in L
Change in pulmonary functions (FVC)
时间窗: baseline and 2 months later
Change in FVC in L
Change in pulmonary functions (FEV1)
时间窗: baseline and 2 months later
Change in FEV1 in L
Change from baseline in concentrations of inflammatory markers
时间窗: baseline and 2 months later
Inflammatory markers include IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, IL-17A, IL-23, IL-33, TNF- α, IFN-γ, CXCL1, CXCL9, and CXCL10 (IP-10) in blood
Change in pulmonary functions (PEF)
时间窗: baseline and 2 months later
Change in PEF in L/sec
Change in oxidative stress marker
时间窗: baseline and 2 months later
Change in urinary 8-OHdG for DNA damage
Change in pulmonary functions (FEF)
时间窗: baseline and 2 months later
Change in FEF in L/sec
次要结局
- Change in blood cholesterol markers(baseline and 2 months later)
- Change in liver function(baseline and 2 months later)
- Change in kidney function(baseline and 2 months later)
- Change in blood sugar (HbA1C)(baseline and 2 months later)
- Change in blood cell count(baseline and 2 months later)
- Change in blood sugar (glucose)(baseline and 2 months later)
研究者
Wen-Harn Pan
Distinguished Research Fellow, Principal Investigator
Academia Sinica, Taiwan