CTRI/2018/10/016102招募中2 期
Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer EMBRACE II - EMBRACE-II
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- PGIMER
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Cancer of the uterine cervix considered suitable for curative treatment with definite radio-chemo therapy including MRI guided brachytherapy
- •2. Positive biopsy showing squamous cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.
- •3.Staging according to FIGO and TNM guidelines.(Stage IB, IIA, IIB, IIIA, IIIB and IVA)
- •4. MRI of pelvis at diagnosis is performed.
- •5. MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed.
- •6. MRI with applicator in place at time of (first) BT will be performed.
- •7. Para-aortic metastatic nodes below L1-L2 are allowed.
- •8. Patient informed consent.
排除标准
- •1. Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin.
- •2. Small cell neuroendocrine cancer, melanoma and other rare cancers in the cervix.
- •3. Metastatic disease above and beyond the retroperitoneal para-aortic L1-L2 interspace.
- •4. Previous pelvic or abdominal radiotherapy.
- •5. Previous total or partial hysterectomy.
- •6. Combination of preoperative radiotherapy with surgery.
- •7. Patient receiving brachytherapy only.
- •8. Patient receiving external radiotherapy only.
- •9. Patients receiving neo-adjuvant chemotherapy or other forms of antineoplastic treatment apart from weekly concomitant cisplatin (40mg/2).However, adjuvant chemotherapy in the form of 4 courses of 3 weekly Carboplatin (AUC 5) and paclitaxel (155mg/m2) is allowed according to the departmental policy.
- •6. Contra indications to MRI.
- •7.Contra indications to brachytherapy.
研究者
相似试验
招募中
2 期
Image based external and internal radiation therapyCTRI/2017/09/009906Tata Memorial Hospital
招募中
2 期
Addition of a Focal boost In external beam Radiotherapy for locally advanced prostate cancer by online adaptive MR-guided radiotherapy (AFFIRM trial)prostate cancerNL-OMON53565Radboud Universitair Medisch Centrum95
招募中
2 期
Short course external beam radio-chemotherapy and single application brachytherapy for cervical cancer – a Phase II studyCTRI/2021/05/033538Homi Bhabha Cancer Hospital and Research Centre unit of Tata Memorial Centre
招募中
2 期
Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical CancerUterine Cervical NeoplasmsNCT03617133Medical University of Vienna1,000
已完成
不适用
Adaptive Dose-Escalated Multi-modality Image-guided RadiothErapy (ADMIRE) for head and neck cancer by twice re-imaging, re-delineation and re-planning during the course of radiotherapyNL-OMON47484Antoni van Leeuwenhoek Ziekenhuis20