临床试验/2024-519726-20-00

2024-519726-20-00招募中4 期

Pre- vs. postoperative thromboprophylaxis for liver resection – a prospective, multicentre, randomized controlled trial (PREPOSTEROUS trial)

Oslo University Hospital HF2 个研究点分布在 1 个国家目标入组 500 人开始时间: 2024年12月19日最近更新: 2024年12月19日

试验速览

阶段: 4 期
状态: 招募中
发起方
入组人数: 500
试验地点: 2
主要终点: Venous thromboembolisms, number of patients, within 30 days from liver resection.

研究概览入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Perioperatively initiated thromboprophylaxis reduces venous thromoboembolism without increasing the risk of bleeding complications.

研究设计

研究类型: Interventional

入排标准

年龄范围: 18 years 至 65+ years（18-64 Years, 65+ Years）
接受健康志愿者: 否

入选标准

•All patients undergoing liver resection

排除标准

•Patient on anti-coagulative medication (heparin, low-molecular weight heparin, warfarin, direct oral anticoagulants) during last month pre-surgery. Emergency operation (e.g., for trauma or infection). Age < 18 years Allergy or other contraindication to planned low-molecular weight heparin. Inability to give written informed consent. Liver resection not performed (removed from analyses after randomization).

结局指标

主要结局

Venous thromboembolisms, number of patients, within 30 days from liver resection.

次要结局

1) Posthepatectomy haemorrhage, any grade in ISGLS classification, number of patients, within 30 days from liver resection 2) Comprehensive Complication Index – score, within 30 days from liver resection 3) Length of postoperative hospital stay, days 4) Total amount of transfused red blood cells, units, during and within 30 days from liver resection

研究者

发起方

Oslo University Hospital HF

申办方类型

Hospital/Clinic/Other health care facility

责任方

Principal Investigator

主要研究者

Sheraz Yaqub

Scientific

Oslo University Hospital HF

研究点 (2)

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