NCT02465281已完成不适用
Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Stroke (Preliminary Study)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Structural and Functional Imaging
研究概览
简要总结
The objective of the preliminary study is:
- To identify correlations between brain lesions and sensorimotor impairments in stroke.
- To identify possible patterns between brain lesions and sensorimotor impairments that might increase our understanding in stroke recovery and guide further tailor-based neuro-rehabilitation
详细描述
The purpose of this study is to investigate arm and hand function after stroke and how the location of the brain lesion affects arm and hand function. We are hoping to collect data in the form of assessments what you feel and how your arm moves, surveys about activities in daily life and well-being, and we will perform 1 Magnetic Resonance Imaging (MRI) scan. MRI scans are loud but painless; nothing is injected. With MRI, we collect images from the brain.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria for healthy subjects are:
- •medically stable;
- •18 - 99 years of age;
- •able to hear the instructions given during the study
- •Inclusion criteria for stroke patients are:
- •at least 6 months post-stroke;
- •medically stable;
- •18 - 99 years of age;
- •subcortical or cortical infarct confirmed with MRI;
- •Mini-mental State Exam > 24/30 (Folstein et al., 1975);
- •able to hear the instructions given during the study;
- •able to comprehend the instructions given during the study;
- •able to commit time to participate in a 6-12-weeks rehabilitation program
排除标准
- •Exclusion criteria for healthy subjects are:
- •having ever experienced a stroke or another brain injury or illness related to the brain that has lasting effects or effects experienced at the moment of recruitment;
- •severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt;
- •contractures in tested arm that hinder persons from keeping the outstretched arm in a relaxed position;
- •interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);
- •exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc);
- •pregnant or nursing mother;
- •adults lacking capacity to consent
- •Exclusion criteria for stroke patients are:
- •insular or cerebellar infarcts/brain lesions;
- •unilateral spatial neglect, identified by a standard neuropsychological assessment (Bell's test (score/35, Gauthier et al., 1989);
- •apraxia (TULIA, Vanbellingen et al., 2011);
- •severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt;
- •contractures in the hemiplegic arm that hinder patients from keeping the outstretched arm in a relaxed position;
- •interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);
- •patients currently receiving therapy for their hemiplegic arm, the latter in order to avoid confounding treatment effects;
- •exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc);
- •pregnant or nursing mother;
- •adults lacking capacity to consent
结局指标
主要结局
Structural and Functional Imaging
时间窗: 1 week
Identify correlations between brain lesions and sensimotor impairments in stroke
Identify Possible Patterns
时间窗: 1 week
Identify possible patterns between brain lesions and senosrimotor impairments that might increase our understanding in stroke recovery and guide further tailor-based neuro-rehabilitation
次要结局
未报告次要终点
研究者
研究点 (1)
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