NCT02385487撤回不适用
Inflammation in Type 2 Myocardial Infarction
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Leukocyte-platelet aggregates
研究概览
简要总结
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand. Although type 2 MI is highly prevalent in patients with critical illness and strongly associated with mortality, the pathophysiology remains poorly understood. Inflammation is central to the development of atherosclerosis, plaque rupture, and other subtypes of MI, but the role of inflammation in type 2 MI and myocardial necrosis has not been defined. The investigators aim to to delineate the mechanistic role of inflammation in myocardial necrosis and type 2 MI complicating critical medical illness.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥21 years of age
- •admitted to the Medical Intensive or Coronary Care Units
- •sepsis or respiratory failure
- •clinically indicated troponin measurement within 24 hours of ICU admission
排除标准
- •unstable angina or Type 1 MI
- •percutaneous or surgical coronary revascularization within 7 days
- •heart failure exacerbation
- •primary valvular disorder
- •aortic dissection
- •infiltrative heart disease or hypertrophic cardiomyopathy
- •myocarditis
- •pulmonary embolism
- •electrocardiogram with >1mm ST segment elevation in two consecutive leads
- •serum cardiac troponin >99th percentile URL but no clear rise or fall pattern
- •history of chronic inflammatory disease
- •use of therapeutic-dose anticoagulants / antiplatelet agents other than aspirin
- •pregnant or incarcerated
- •enrolled in a competing study
结局指标
主要结局
Leukocyte-platelet aggregates
时间窗: Day 1
次要结局
- Monocyte-platelet aggregates(Day 10)
- Leukocyte-platelet aggregates(Day 10)
- Neutrophil-platelet aggregates(Day 10)
研究者
研究点 (1)
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